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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (10): 1744-1749. 上一篇    下一篇

研究论文

N-苯基和N-乙氧羰基甲基磷异喹啉酮及其衍生物的合成

丁 一a; 丁贻祥*,b   

  1. (a上海师范大学生命与环境科学学院 上海 200234)
    (b中国科学院上海有机化学研究所 上海 200032)
  • 收稿日期:2008-03-17 修回日期:2008-04-28 发布日期:2008-10-20
  • 通讯作者: 丁贻祥

Synthesis of N-Phenyl and N-Ethoxycarbonylmethyl Phosphaisoqui-nolin-1-ones and Their Derivatives

DING, Yia ; DING, Yi-Xiang*,b   

  1. (a College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234)
    (b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)
  • Received:2008-03-17 Revised:2008-04-28 Published:2008-10-20
  • Contact: DING, Yia

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被引次数

1

以邻炔基苯磷酰胺为原料经Pd(II)催化的环化反应、环化偶联反应和氯环化反应高收率合成了15个N-苯基和N-乙氧羰基甲基磷异喹啉酮及其4-烯丙基、4-氯衍生物, 它们的结构均经过1H NMR, 13C NMR, MS, IR及元素分析确证.

关键词: 4-取代磷异喹啉酮, N-苯基磷异喹啉酮, 氯环化, N-乙氧羰基甲基磷异喹啉酮, 环化偶联, 环化

Fifteen N-phenyl and N-ethoxycarbonylmethyl phosphaisoquinolin-1-ones and their 4-allyl, 4-chloro derivatives were synthesized by Pd(II)-catalyzed cyclization, coupling-cyclization and halocyclization reactions. The structures of the target compounds were confirmed by 1H NMR, 13C NMR, MS, IR spectra and elemental analysis.

Key words: N-ethyloxygencarbonylmethylphosphaisoquinolin-1-one, N-phenyphosphaisoquinolin-1-one, cyclization, 4-substituent phosphaisoquinolin-1-one, halocyclization, coupling-cyclization