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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (01): 20-33. 上一篇    下一篇

综述与进展

印楝素的合成、结构修饰及生物活性研究进展

樊会丹a ; 张从海a ; 严胜骄a ; 林 军*,a,b   

  1. (a云南大学化学科学与工程学院 教育部自然资源药物化学重点实验室 昆明 650091)
    (b南开大学元素有机化学研究所元素有机化学国家重点实验室 天津 300071)
  • 收稿日期:2008-03-08 修回日期:2008-04-29 发布日期:2009-01-20
  • 通讯作者: 林 军

Advances of Synthesis and Structure Modification and Bioactivity of Azadirachtin

Fan, Huidana ; Zhang, Conghaia; Yan, Shengjiaoa ; Lin, Jun*,a,b   

  1. (a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and
    Technology, Yunnan University, Kunming 650091)
    (b State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University,
    Tianjin 300071)
  • Received:2008-03-08 Revised:2008-04-29 Published:2009-01-20
  • Contact: Lin, Jun

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1853

被引次数

48 | 9

自印楝素被分离鉴定以来, 其广谱而独特的生物活性受到人们的广泛关注, 已成为一种近乎完美的植物源杀虫剂; 且在医药、保健、日化等领域都有广泛的应用．其复杂而独特的分子结构使得科研工作者进行了大量的全合成尝试、结构修饰及构效关系等研究. 综述了印楝素A的片段合成、全合成和印楝素有关的结构修饰以及生物活性等方面的研究进展.

关键词: 生物活性, 印楝素, 全合成, 结构修饰

Since azadirachtin was first isolated and identified, the general and unique bioactivities have attracted considerable research effort. It is an excellent botanical pesticide used widely in agriculture presently, and also used in the fields of medicine, health and commodity. The progress of total synthesis, structure modification and biological activities of azadirachtin is reviewed.

Key words: total synthesis, structure modification, bioactivity, azadirachtin