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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (01): 44-54. 上一篇    下一篇

综述与进展

钯催化合成嘧啶核苷衍生物的研究进展

靳玄烨a ; 肖 强*,b; 巨 勇*,a   

  1. (a清华大学化学系 生命有机磷与化学生物学教育部重点实验室 北京 100084)
    (b 江西科技师范学院有机功能分子重点实验室 南昌330013)
  • 收稿日期:2007-11-08 修回日期:2008-06-03 发布日期:2009-01-20
  • 通讯作者: 肖 强*,b; 巨 勇*,a

Progress in Palladium-Catalyzed Synthesis of Pyrimidine Nucleoside Derivatives

Jin, Xuanyea ; Xiao, Qiang*,b ; Ju, Yong*,a   

  1. (a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education,
    Department of Chemistry, Tsinghua University, Beijing 100084)
    (bJiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013)
  • Received:2007-11-08 Revised:2008-06-03 Published:2009-01-20
  • Contact: Xiao, Qiang*,b ; Ju, Yong*,a

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1621

被引次数

23 | 6

嘧啶核苷衍生物在药物化学、生物探针和核酸化学的研究中具有重要的作用, 金属催化碳碳的形成广泛应用于嘧啶核苷衍生物的合成. 综述了钯催化的Sonogashira反应、Stille反应、Heck反应以及Hiyama反应在嘧啶类核苷衍生物合成中的应用.

关键词: Heck反应, Hiyama反应, 嘧啶核苷, Sonogashira反应, Stille反应

Pyrimidine nucleosides are of great importance for medicinal chemistry, biological probe and nucleic acid. Palladium-catalyzed formation of carbon-carbon bond has found broad application to the synthesis of pyrimidine nucleoside derivatives. In this paper, the application and mechanism of some important palladium-catalyzed reactions used for the synthesis of pyrimidine nucleoside derivatives are summarized, which include Sonogashira reaction, Stille reaction, Heck reaction and Hiyama reaction.

Key words: Sonogashira reaction, Hiyama reactio, Stille reaction, Heck reaction, pyrimidine nucleoside