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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (07): 1133-1137. 上一篇    下一篇

研究简报

一步法合成噻唑并[3,2-b](1,2,4)-三唑类衍生物的研究

王德忠; 张正强; 张莉莉; 史海健*   

  1. (南京工业大学化学化工学院 南京 210009)
  • 收稿日期:2008-06-30 修回日期:2006-12-26 发布日期:2009-07-22
  • 通讯作者: 史海健

One-Pot Synthesis of Thiazolo[3,2-b](1,2,4)-triazoles

Wang, Dezhong; Zhang, Zhengqiang ; Zhang, Lili; Shi, Haijian*   

  1. (College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing 210009)
  • Received:2008-06-30 Revised:2006-12-26 Published:2009-07-22
  • Contact: Shi, Haijian

PDF

1225

被引次数

6

以3-芳基-5-巯基-1,2,4-三唑为原料, 在酸性条件下与乙酰丙酮和乙酰乙酸乙酯一步成环, 制备得到12种新的2-芳基-5-取代-6-甲基噻唑并[3,2-b](1,2,4)-三唑类衍生物. 所有化合物结构经IR, 1H NMR, 13C NMR 和MS及元素分析确证.

关键词: 噻唑并三唑, 衍生物, 酸性条件

Twelve novel compounds, 5-(substituted phenyl)-2-substituent-3-methylthiazolo[3,2-b](1,2,4)- triazole derivatives, were synthesized by a one-pot reaction of 3-(substituted phenyl)-4,5-dihydro-1,2,4- triazole-5-thiones with acetylacetone or acetylacetic ester in the presence of acid. The structures of the com-pounds were confirmed by IR, 1H NMR, 13C NMR, MS techniques and elemental analysis.

Key words: derivative, acidic condition, thiazolo-triazole