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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (02): 233-237. 上一篇    下一篇

研究论文

微波辐射下一锅法合成2-氨基-6-溴-4-芳基-5H-茚并[1,2-b]吡啶-3-腈衍生物

季春香1，薛永震2，王建强1，殷俊1，崔永涛1，郭成*,1   

  1. (1南京工业大学理学院 南京 210009)
    (2南京化工研究院 南京 210033)
  • 收稿日期:2009-02-16 修回日期:2009-05-18 发布日期:2010-03-30
  • 通讯作者: 郭成 E-mail:guocheng@njut.edu.cn

One-Pot Synthesis of 2-Amino-6-bromo-4-(substituted phenyl)-5H- indeno[1,2-b]pyridine-3-carbonitrile De-rivatives under Microwave Irradiation

Ji Chunxiang1 Xue Yongzhen2 Wang Jian-qiang1 Yin Jun1 Cui Yongtao1 Guo Cheng*,1   

  1. (1 College of Sciences, Nanjing University of Technology, Nanjing 210009)
    (2 Nanjing Institute of Chemical Industry, Nanjing 210033)
  • Received:2009-02-16 Revised:2009-05-18 Published:2010-03-30
  • Contact: Cheng Guo E-mail:guocheng@njut.edu.cn

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以芳香醛、4-溴茚酮、丙二腈和醋酸铵为原料, 分别用微波辐射和传统加热法, 一步法合成7种未见文献报道的2-氨基-6-溴基-4-芳基-5H-茚并[1,2-b]吡啶-3-腈衍生物. 对比两种方法, 在常压下微波具有反应时间短、产率较高等特点. 所有化合物均经IR, 1H NMR和元素分析确定.

关键词: 4-溴茚酮, 微波辐射, 茚并[1,2-b]吡啶, 传统加热

Seven new 2-amino-6-bromo-4-(substituted phenyl)-5H-indeno[1,2-b]pyridine-3-carbonitrile derivatives were synthesized by using benzaldehydes, 4-bromo-indan-1-one and malononitrile in one-pot via conventional heating and microwave irradiation techniques. By comparison of the two methods, the microwave irradiation possessed such advantages as short reaction time, high yields and so on over the conventional method under normal pressure. The structures of these compounds were characterized by IR, 1H NMR spectra and elemental analysis.

Key words: 4-bromo-indanone, microwave irradiation, indeno[1,2-b]pyridine, conventional heating