有机化学 ›› 2010, Vol. 30 ›› Issue (03): 317-329.    下一篇

综述与进展

抗肿瘤活性四氢异喹啉生物碱全合成研究进展

廖祥伟 董文芳 刘 伟 陈世智 刘站柱   

  1. (中国医学科学院北京协和医学院药物研究所 北京100050)
  • 收稿日期:2008-11-13 修回日期:2009-06-20 发布日期:2010-03-28

Synthetic Progress of the Tetrahydroisoquinoline Antitumor Alkaloids

Liao, Xiangwei Dong, Wenfang Liu, Wei Chen, Shizhi Liu, Zhanzhu   

  1. (Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050)
  • Received:2008-11-13 Revised:2009-06-20 Published:2010-03-28

综述了近年来抗肿瘤活性四氢异喹啉生物碱Renieramycin, Ecteinascidin和Quinocarcin的全合成研究进展, 对其构环顺序和方法进行了分析, 对部分合成路线的优缺点进行了讨论.

关键词: 四氢异喹啉生物碱, Renieramycins, Ecteinascidins, Quinocarcin, 全合成

The recent advance in the total synthesis of the tetrahydroisoquinoline alkaloids is reviewed, including renieramycins, ecteinascidins and quinocarcin. The strategies and sequences to construct the skeleton have been analyzed. Some advantages or limitations of the synthetic routes have also been discussed.

Key words: tetrahydroisoquinoline alkaloid, renieramycin, ecteinascidin, quinocarcin, total synthesis