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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (07): 1072-1075. 上一篇    下一篇

研究简报

Mg(NTf)催化Friedl?nder缩合反应合成喹啉衍生物

王宏社*，曾君娥   

  1. (宝鸡文理学院化学化工系 陕西省植物化学重点实验室 宝鸡 721013)
  • 收稿日期:2009-03-23 修回日期:2010-02-09 发布日期:2010-02-23
  • 通讯作者: 王宏社 E-mail:hongshewang@126.com
  • 基金资助:

    陕西省植物化学重点实验室基金(No. 08JZ09)；宝鸡文理学院重点科研项目(No.Zk064)

Mg(NTf) Catalyzed Efficient Synthesis of Quinoline Derivatives via Friedl?nder Condensation Reaction

WANG Hong-She, ZENG Jun-E   

  1. (Shaanxi Key Laboratory for Phytochemistry, Department of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013)
  • Received:2009-03-23 Revised:2010-02-09 Published:2010-02-23

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以Mg(NTf)为催化剂, 在室温由2-氨基芳基酮和α-亚甲基酮通过Friedl?nder缩合反应合成了喹啉衍生物. 该法操作简便, 反应条件温和, 产率高, 反应时间短.

关键词: Mg(NTf), 喹啉衍生物, Friedl?nder缩合反应, 催化

Quinoline derivatives have been synthesized via Friedl?nder condensation reaction of 2-aminoaryl ketones with α-methylene ketones in the presence of 1 mol% Mg(NTf) at room temperature. The advantages of this method are easy work-up, mild reaction conditions, high yield and short reaction time.

Key words: Mg(NTf), quinoline derivative, Friedl?nder condensation reaction, catalysis