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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (12): 2173-2177. 上一篇    下一篇

研究简报

一锅法Kumada偶联反应合成烷基吡啶化合物

刘涛平，谢俊杰，李彬，蔡良珍*，陶晓春*   

  1. (华东理工大学化学与分子工程学院 上海 200237)
  • 收稿日期:2011-07-03 修回日期:2011-09-15 发布日期:2011-09-30
  • 通讯作者: 陶晓春 E-mail:xctao@ecust.edu.cn

Synthesis of Alkylpyridines via One-Pot Kumada Reaction

LIU Tao-Ping, XIE Jun-Jie, LI Bin, CAI Liang-Zhen, TAO Xiao-Chun   

  1. (School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237)
  • Received:2011-07-03 Revised:2011-09-15 Published:2011-09-30

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以溴代吡啶为原料, 用简单结构的镍化合物(Py4NiCl2)作为催化剂, 经过一锅法Kumada偶联反应合成一系列甲基、烯丙基或苄基取代的吡啶化合物, 收率在中等以上.

关键词: Kumada偶联反应, 溴代吡啶, 镍催化, 一锅法

A series of methyl-, allyl-, benzyl-substituted pyridines were prepared in moderate yield, using bromopyridines as starting material and a simple structure nickel complex (Py4NiCl2) as catalyst by one-pot Kumada reaction.

Key words: Kumada reaction, bromopyridine, nickel-catalyzed, one-pot