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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (03): 479-483. 上一篇    下一篇

研究简报

含吡啶环的[1,3,4]噁二唑类化合物的合成及表征

李志芬a，张敏*,a，崔利英a,b，陆东亮a，黄培刚a，张军a   

  1. (a上海大学理学院化学系 上海 200444)
    (b四川省攀枝花市白丽坡煤化工厂 攀枝花 617005)
  • 收稿日期:2006-11-01 修回日期:2007-07-27 发布日期:2008-03-18
  • 通讯作者: 张敏

Synthesis and Structural Characterization of 1,3,4-Oxadiazoles Bearing Pyridine Ring

LI Zhi-Fena,ZHANG Min*,a,CUI Li-Yinga,b,LU Dong-Lianga
HUANG Pei-Ganga,ZHANG Juna   

  1. (a Department of Chemistry, Shanghai University, Shanghai 200444)
    (b The Coal Factory of Bailipo, Panzhihua 617005)
  • Received:2006-11-01 Revised:2007-07-27 Published:2008-03-18
  • Contact: ZHANG Min

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1712

被引次数

6

2,6-二甲基吡啶-3,5-二甲酸二乙酯在乙醇中与水合肼反应生成5-甲酰肼基-2,6-二甲基吡啶甲酸乙酯和2,6-二甲基吡啶-3,5-双酰肼, 使其与取代的苯甲醛反应, 得到相应的腙, 最后在N-溴代丁二酰亚胺(NBS)作用下成环. 化合物的结构分别通过了1H NMR, IR, MS, 元素分析确证.

关键词: 吡啶, [1,3,4]噁二唑, 酰肼, NBS, 酰腙

2,6-Dimethyl-5-ethoxycarbonylpyridine-3-hydrazide and 2,6-dimethylpyridine-3,5-dihydrazide were synthesized by the reaction of diethyl 2,6-dimethylpyridine-3,5-dicarboxylate with hydrazine hydrate in ethanol, then, reacted with substituted benzaldehyde to obtain N-acylhydrazones. At last, a series of new target compounds were formed in the presence of N-bromosuccinimide, which were characterized by 1H NMR, IR, MS spectra and elemental analyses.

Key words: N-acylhydrazone, pyridine, hydrazide, N-bromosuccinimide, 1,3,4-oxadiazole