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有机化学
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有机化学 ›› 2003, Vol. 23 ›› Issue (9): 953-957. 上一篇    下一篇

研究论文

海绵Phacelliafusca中含氮化合物的分离与结构鉴定

徐效华;姚广民;孔垂华;李艳明;林长江;王昕;苏镜娱;曾陇梅   

  1. 南开大学元素有机化学研究所;中山大学化学系
  • 发布日期:2003-09-25

Four Compounds Containning Nitrogen from Marine Sponge Phacellia fusca Schmidt

Xu Xiaohua;Yao Guangmin;Kong Chuihua;Li Yanming;Lin Changjiang;Wang Xin;Su Jingyu;Zeng Longmei   

  1. State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University;Department of Chemistry, Zhongshan University
  • Published:2003-09-25

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780

被引次数

15

从采自中国南海西沙群岛海域的海绵Phacellia fusca Schmidt中得到4个含氮 化合物。经~1H NMR,~(13)C NMR,HMQC,HMBC,~1H-~1HCOSY,FABMS和EIMS等光谱分析 ，确证其结构分别为：N,N'-二[2-乙氧基-1（Z）-乙烯基]脲（1），2- Bromoaldisin(2),Aldisin(3)Dibromophakellin盐酸盐(4)。其中化合物1为一具有 对称结构的新脲类化合物，命名Phacelliaurea A；化合物4是首次从该海绵中分离 得到的已知胍基生物碱，首次报到了它的~(13)C NMR数据及其归属。

关键词: 海绵, 生物碱, 质子磁共振谱法, 碳十三核磁共振谱法, 脲

Four compounds containning nitrogen have been isolated from the sponge Phacellia fusca Schmidt, collected from the Xisha Islands in the South China Sea. The structures of these compounds were characterized by ~1H NMR, ~(13)CNMR, HMQC, HMBC, ~1H-~1HCOSY, FABMS and EIMS as N, JV'-bis[2-ethoxyl-l(Z)-vinyl] urea (1), 2-bromoaldisin (2), aldisin (3) and dibromophakellin (4). Among them, compound 1 is a new urea, containing a symmetrical partial structure, named as phacelliaurea A. Compound 4 is a known guam'dine alkaloid, first isolated from the sponge Phacellia fusca Schmidt, and the data and assignments of its ~(13)C NMR was first reported.

Key words: marine sponge, ALKALOID, 1HNMR, C13NMR, UREA

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