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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (06): 685-695.    下一篇

综述与进展

抗HIV天然产物Calanolide A及其类似物的合成进展

杨光忠*,a，陈玉b   

  1. (a中南民族大学生命科学学院民族药物研究所 武昌 430074)
    (b中南民族大学化学与材料学院 武昌 430074)
  • 收稿日期:2006-05-08 修回日期:2006-08-29 发布日期:2007-05-21
  • 通讯作者: 杨光忠

Progress in Total Synthesis of Calanolide A and Its Analogues

YANG Guang-Zhong*,a, CHEN Yub   

  1. (a National Medicine Institute, College of Life Sciences, South-Central University for Nationalities, Wuhan 430074)
    (b College of Chemistry and Material Sciences, South Central University for Nationalities, Wuhan 430074)
  • Received:2006-05-08 Revised:2006-08-29 Published:2007-05-21
  • Contact: YANG Guang-Zhong

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Calanolide A是从藤黄科红厚壳属植物(Calophyllum lanigerum)中分离的一种吡喃型香豆素类化合物, 对HIV-1- RT有很强的抑制作用, 是目前抗HIV的热点先导物. 综述了该化合物及其类似物的全合成研究进展, 分析了它的合成路线, 讨论了各合成方法的优缺点.

关键词: 全合成, 抗-HIV, Calanolide A

Calanolide A was a kind of pyranocoumarin which was isolated from Calophyllum genus plant. It showed strong inhibition against HIV-1-RT, and was a top lead compound of anti-HIV. In this paper, the to-tal synthesis of calanolide A and its analogues has been reviewed. Each synthetic route has been analyzed. Both merits and limitations of synthetic method have been discussed.

Key words: total synthesis, anti-HIV, calanolide A