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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (2): 343-347. 上一篇    下一篇

研究简报

2-(3-芳氧甲基-4-苯基-1,2,4-三唑-5-硫基)乙酸的微波合成及生物活性研究

王良成，唐静，魏太保，张有明*   

  1. (西北师范大学化学化工学院 甘肃省高分子重点实验室 兰州 730070)
  • 收稿日期:2007-06-07 修回日期:2007-08-17 发布日期:2008-02-01
  • 通讯作者: 张有明

Synthesis and Biological Activity of 2-(3-Phenoxymethyl-4- phenyl-[1,2,4]triazole-5-thio)acetic Acid

WANG Liang-Cheng,TANG Jing,WEI Tai-Bao,ZHANG You-Ming*   

  1. (Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering,
    Northwest Normal University, Lanzhou 730070)
  • Received:2007-06-07 Revised:2007-08-17 Published:2008-02-01
  • Contact: ZHANG You-Ming

PDF

631

被引次数

23

在微波辐射条件下, 芳氧乙酰肼经两步反应制得4-苯基-3-芳氧甲基-1,2,4-三唑-5-硫酮衍生物, 再与氯乙酸反应得到6种尚未见文献报道的2-(3-芳氧甲基-4-苯基-1,2,4-三唑-5-硫基)乙酸衍生物. 目标化合物的结构经IR, 1H NMR和元素分析进行了确证. 生物活性试验结果表明, 该类化合物对双子叶植物油菜具有良好的生物调节活性.

关键词: 2-(3-芳氧甲基-4-苯基-1,2,4-三唑-5-硫基)乙酸, 生物活性, 微波合成, 三唑

Six derivatives of 4-phenyl-3-phenoloxymethyl-5-mercapto-1,2,4-triazlyole were synthesized from phenoloxyacetyl hydrazide by two-steps reaction under microwave irradiation, then reacted with 2-chloroacetic acid to give six novel derivatives of 2-(3-phenoxymethyl-4-phenyl-[1,2,4]triazole-5-thio)- acetic acid. All the products were characterized by elemental analysis, FT-IR and 1H NMR spectra. The preliminary biological activity tests showed that all the compounds have obvious regulating activities for the growth of cole.

Key words: biology activity, 2-(3-phenoxymethyl-4-phenyl-[1,2,4]triazole-5-thio)acetic acid, microwave irradiation, triazole