有机化学 ›› 2008, Vol. 28 ›› Issue (11): 1911-1917. 上一篇    下一篇

综述与进展

ent-贝壳杉烷型二萜化合物的细胞毒活性研究进展

张大永; 李子元 ; 施连勇; 吴晓明*; 华维一   

  1. (中国药科大学药学院 南京 210009)
  • 收稿日期:2007-11-20 修回日期:2008-04-14 发布日期:2008-11-18
  • 通讯作者: 吴晓明

Advances in Research on Cytotoxinic Activity of ent-Kaurane Diterpenoids

ZHANG, Da-Yong; LI, Zi-Yuan ; SHI, Lian-Yong; WU, Xiao-Ming*; HUA, Wei-Yi   

  1. (School of Pharmacy, China Pharmaceutical University, Nanjing 210009)
  • Received:2007-11-20 Revised:2008-04-14 Published:2008-11-18
  • Contact: WU, Xiao-Ming

详细地概述了各类天然与合成的ent-贝壳杉烷二萜化合物的细胞毒活性研究进展, 总结和讨论了这类化合物的构效关系、作用机制以及对多种人癌细胞系的选择性, 评述了这类化合物作为抗肿瘤药物的开发潜力, 提出了目前存在的问题与不足, 并对其发展前景和研究方向做出了预测和展望.

关键词: ent-贝壳杉烷二萜化合物, 肿瘤细胞系选择性, 细胞毒活性, 作用机制, 构效关系

The recent progress in natural or synthetical ent-kaurane diterpenoids possessing definite cytotoxinic activity is reviewed in detail, the structure-activity relationships, mechanisms and selectivities upon multiple human tumor cell lines are discussed, the potential for the development as prospective anti-tumor drugs is evaluated, some temporary problems are summarized, and the prospects of the development and the directions of the research are anticipated.

Key words: ent-kaurane diterpenoid, structure-activity relationship, selectivity to tumor cell line, mechanism, cytotoxinic activity