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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (02): 181-199. 上一篇    下一篇

综述与进展

铜催化C-N交叉偶联反应的研究进展

王晔峰*，曾京辉*，崔晓瑞   

  1. (陕西师范大学化学与材料科学学院 陕西省大分子重点实验室 西安 710062)
  • 收稿日期:2009-03-10 修回日期:2009-05-24 发布日期:2010-02-20
  • 通讯作者: 王晔峰 E-mail:jhzeng@ustc.edu

Recent Progress in Copper-Catalyzed C-N Coupling Reactions

Wang Yefeng* Zeng Jinghui* Cui Xiaorui   

  1. (School of Chemistry and Materials Science, Shaanxi Normal University, Xi’an 710062)
  • Received:2009-03-10 Revised:2009-05-24 Published:2010-02-20
  • Contact: Ye Feng Wang E-mail:jhzeng@ustc.edu

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被引次数

76 | 14

对铜催化的C-N交叉偶联反应的最新研究进展作了综述. 按照反应中含氮化合物种类的不同将亲核试剂分为氨基酸、胺、酰胺、含氮芳香杂环化合物、其它含氮化合物五类, 对各类亲核试剂参与反应的体系(包括亲电试剂、催化剂前驱体、配体、溶剂、温度、碱、反应时间)做了全面归纳, 在此基础上以配体为主线对各类亲核试剂涉及的反应进一步做了详细介绍. 另外, 对这一反应的机理研究也做了综述.

关键词: C-N交叉偶联反应, 铜, 催化, 进展

The recent progress in copper-catalyzed C-N cross-coupling reactions is reviewed. According to the different compounds containing nitrogen, the nucleophiles are divied into the following five categories: amino acids, amines, amides, aromatic nitrogen heterocycles and others nitrogenous compounds. The reaction systems, in which the reaction of various types of nucleophiles were carried out, including electrophile, catalyst precusor, ligand, solvent, temperature, base and reaction time, are summarized comprehensively. Based on the ligands the above rections are described in detail. Furthermore, the studies on the mechanism of these reactions are surveyed.

Key words: C-N cross-coupling reaction, Cu, catalysis, progress