有机化学 ›› 2012, Vol. 32 ›› Issue (05): 930-933.DOI: 10.6023/cjoc1111173 上一篇    下一篇

研究简报

ZSM-5 催化一锅法合成3-(5′-取代-2’-苯并噁唑基)-7-二乙基氨基-2H-1-苯并吡喃-2-酮

蒋绍亮a, 韩亮b   

  1. a 浙江工业大学药学院, 浙江工业大学工业催化学科 杭州 310032;
    b 浙江工业大学化材学院, 杭州 310032
  • 收稿日期:2012-01-29 修回日期:2012-03-05 发布日期:2012-03-31
  • 通讯作者: 韩亮 E-mail:hanliang814@163.com
  • 基金资助:

    浙江省自然科学基金(No. Y12B030037)和浙江省教育厅基金(No. Y201018410)资助项目.

One-pot synthesis of 3-(5’-subsituted-benzoxazol-2’-yl)-7-diethylamino-chromen-2-one catalyzed with ZSM-5

Jiang Shaolianga, Han Liangb   

  1. a College of Pharmaceutical Science, Industial Catalysis Subjects, Zhejiang University of Technology, Hangzhou 310032;
    b College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032
  • Received:2012-01-29 Revised:2012-03-05 Published:2012-03-31
  • Supported by:

    Project supported by the Natural Science Foundation of Zhejiang Province (No. Y12B030037) and the Foundation of Department of Education of Zhejiang Province (No. Y201018410).

以绿色环保的固体酸ZSM-5 分子筛为催化剂,正丁醇为溶剂,4-位取代邻氨基苯酚、4-二乙氨基水杨醛和氰乙酸乙酯三组分一锅法合成了香豆素类化合物3-(5′-取代-2′-苯并噁唑基)-7-二乙基氨基-2H-1-苯并吡喃-2-酮。与液体酸催化相比,该方法具有收率更高,环境友好等优点。

关键词: 香豆素, 固体酸催化, 一锅法合成, ZSM-5 分子筛

3-(5’-subsituted-benzooxazol-2’-yl)-7-diethylamino-chromen-2-ones were prepared by one pot three-component reaction of 4-diethylaminosalicylaldehydes, ethyl cyanoacetate and o-aminophenols in refluxing n-butanol catalyzed with ZSM-5. This method has advantages of better yields and more environment-friendly process compared with that catalyzed with liquid catalysts.

Key words: Coumarin, solid acid catalyst, One-pot synthesis, ZSM-5 zeolite