有机化学 ›› 2012, Vol. 32 ›› Issue (11): 2177-2180.DOI: 10.6023/cjoc201206010 上一篇    下一篇

研究简报

无碱条件下由芳香醛肟和磺酰氯制备O-磺酰基芳香醛肟

邓桂胜a,b, 莫宏华a, 罗景a, 汤力a   

  1. a 湖南师范大学化学化工学院 长沙 410081;
    b 化学生物学及中药分析教育部重点实验室(湖南师范大学) 长沙 410081
  • 收稿日期:2012-06-08 修回日期:2012-06-28 发布日期:2012-07-11
  • 通讯作者: 邓桂胜 E-mail:gsdeng@hunnu.edu.cn

Base-Free Method for Preparation of O-Sulfonyl Aldoximes Starting from Aldoximes and Sulfonyl Chlorides

Deng Guishenga,b, Mo Honghuaa, Luo Jinga, Tang Lia   

  1. a College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081;
    b Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Hunan Normal University), Ministry of Education, Changsha 410081
  • Received:2012-06-08 Revised:2012-06-28 Published:2012-07-11

在氧化银和碘化钾存在下, 磺酰氯与肟室温反应合成一系列O-磺酰基肟. 芳香醛肟和酮肟作为底物, 产率 56%~87%. 不过, 对硝基苯甲醛肟、脂肪醛肟及α,β-不饱和醛肟作为该反应底物时, 没有获得目标产物.

关键词: O-磺酰基肟, 合成, 肟, 磺酰氯, 氧化银

A series of O-sulfonyl oxime derivatives have been synthesized by the reaction of oximes with sulfonyl chlorides in the presence of silver oxide and potassium iodide. In the case of aromatic aldoximes and ketoximes, desired products were obtained in 56%~87% yields. But then no desired products were obtained when p-nitrobenzaldoxime, aliphatic aldoximes and α,β-unsaturated aldoximes were employed as substrates in the process.

Key words: O-sulfonyl oximes, synthesis, oximes, sulfonyl chlorides, silver oxide