不对称有机催化Michael加成/半缩醛胺化/酰亚胺正离子环化串联反应研究进展

doi:10.6023/cjoc201208032

摘要/Abstract

随着近十多年来不对称有机小分子催化的发展, 以这类催化为基础的串联反应也取得了很大的进展. 综述了近几年来不对称有机催化Michael加成/半缩醛胺化/酰亚胺正离子环化串联反应构建手性氮杂多环结构的研究进展, 介绍了国内外多个课题组对这一类反应的研究结果以及该类反应在生物碱合成中的应用.

关键词: 有机催化, 串联反应, 氮杂多环, 生物碱

During the last decades along with the development of asymmetric organocatalysis, tremendous achievements have been made in asymmetric organocatalytic domino or cascade reactions. Herein, the examples of domino or cascade reactions based on asymmetric organocatalyzed Michael addition are described. More specifically, this review aims to cover and discuss the hemi-aminoacetalyzation/acylimminium-cyclization initiated by Michael addition, and the application of this type of reactions in the synthesis of alkaloids.

Key words: organocatalysis, cascade reaction, N-containing multi cycles, alkaloid

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陈杰, 刘钦, 戴小鸯, 聂凛凛, 房辉辉, 吴小余. 不对称有机催化Michael加成/半缩醛胺化/酰亚胺正离子环化串联反应研究进展[J]. 有机化学, 2013, 33(01): 1-17.

Chen Jie, Liu Qin, Dai Xiaoyang, Nie Linlin, Fang Huihui, Wu Xiaoyu. Progress in Asymmetric Organocatalyzed Michael Addition/Hemi-aminoacetalization/Acylimminium-Cyclization Cascade Reactions[J]. Chin. J. Org. Chem., 2013, 33(01): 1-17.

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