有机化学 ›› 2015, Vol. 35 ›› Issue (5): 1009-1021.DOI: 10.6023/cjoc201409038 上一篇    下一篇

综述与进展

石蒜碱的全合成及结构修饰研究进展

刘颖杰a, 丁泽洋c, 谭冲a, 袁洪亮b, 季宇彬a,b   

  1. a 哈尔滨商业大学商业工程研究院 哈尔滨 150076;
    b 哈尔滨商业大学生命科学与环境科学研究中心 哈尔滨 150076;
    c 吉林大学化学学院 长春 130000
  • 收稿日期:2014-09-24 修回日期:2014-10-29 发布日期:2014-12-10
  • 通讯作者: 季宇彬 E-mail:lyj850527@163.com
  • 基金资助:

    哈尔滨商业大学博士科研启动项目(No.14LG12)、哈尔滨商业大学青年教师自然科学基金(No.HCUL2013019)资助项目.

Progresses in the Total Synthesis and Structure Modification Studies of Lycorine

Liu Yingjiea, Ding Zeyangc, Tan Chonga, Yuan Hongliangb, Ji Yubina,b   

  1. a Business Engineering Research Institute, Harbin University of Commerce, Harbin 150076;
    b Research Center on Life Science and Enviromental Science, Harbin University of Commerce, Harbin 150076;
    c College of Chemistry, Jilin University, Changchun 130000
  • Received:2014-09-24 Revised:2014-10-29 Published:2014-12-10
  • Supported by:

    Project supported by the Harbin University of Commerce Doctoral Research Project (No.14LG12) and the Natural Science Fund for Young Teachers of Harbin University of Commerce (No.HCUL2013019).

石蒜碱是石蒜科生物碱中非常重要的一类异喹啉生物碱衍生物, 近年来药物及有机化学工作者发现石蒜碱及其衍生物具有抗肿瘤、抗炎、抑制乙酰胆碱酯酶、抗疟疾、保护心血管等多种作用, 由于其复杂而独特的分子结构和广泛的药理活性使得科研工作者们进行了大量的全合成尝试及结构修饰等研究. 作者对石蒜碱的全合成及其结构修饰进行了综述.

关键词: 石蒜碱, 全合成, 衍生物, 结构修饰

Lycorine is a very important class of isoquinoline alkaloids of the amaryllidaceae alkaloids. In recent years, pharmaceutical and organic chemists discovered that lycorine and their derivatives have anti-tumor, anti-inflammatory, inhibiting acetylcholinesterase, anti-malarial, cardiovascular protection and other effects. Because of its complex and unique molecular structure and extensive pharmaceutical activities, lycorine has attracted considerable research effort. The recent progresses in the synthesis and structural modification of lycorine are summarized in this review.

Key words: lycorine, total synthesis, derivatives, structure modification