贝壳杉烷型二萜合成进展

doi:10.6023/cjoc201509027

摘要/Abstract

贝壳杉烷型二萜, 特别是对映-贝壳杉烷型二萜是萜类天然产物家族中的主要组成部分. 这类分子通常表现出抗菌、抗肿瘤、抗疟、抗病毒等多种重要生物活性. 在分子结构上, 这类四环二萜分子可以通过分子内氧化反应, 切断反应以及重排反应, 展现出复杂多样性. 因此, 对这类分子的全合成研究始终是国内外合成化学家的重点研究方向. 根据这类分子的不同结构类型, 分类阐述了近期国内外学者对此类分子的全合成研究.

关键词: 二萜, 对映-贝壳杉烷, 全合成

Kaurane, especially ent-kaurane diterpenoids are integral parts of terpenoid natural products, and possess various bioactivities, including antibacterial, antitumor, antimalarial and antiviral activities. Additionally, as a result of intramolecular oxidations, cleavages and rearrangements, the tetracyclic ent-kaurane also shows attractive structural diversity. Hence, the total syntheses of ent-kauranes have evoked a great deal of interest in the synthetic community. This review presents the recent advances in the synthesis of ent-kaurane and kauranediterpenoids.

Key words: diterpenoids, ent-kaurane, total synthesis

引用此文

杜明军, 雷晓光. 贝壳杉烷型二萜合成进展[J]. 有机化学, 2015, 35(12): 2447-2464.

Du Mingjun, Lei Xiaoguang. Advanced in the Synthesis of Kaurane Diterpenoids[J]. Chin. J. Org. Chem., 2015, 35(12): 2447-2464.

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