有机化学 ›› 2016, Vol. 36 ›› Issue (7): 1636-1642.DOI: 10.6023/cjoc201602007 上一篇    下一篇

研究论文

镍催化芳基三氟甲磺酸酯对醛的加成反应及偶联反应

张鸣頔, 陈斌, 葛晨, 刘人荣, 高建荣, 贾义霞   

  1. 浙江工业大学化学工程学院 杭州 310014
  • 收稿日期:2016-02-03 修回日期:2016-03-09 发布日期:2016-03-18
  • 通讯作者: 贾义霞 E-mail:yxjia@zjut.edu.cn
  • 基金资助:

    国家自然科学基金(No.21372202)和新世纪优秀人才支持计划(No.NCET-12-1086)资助项目.

Nickel-Catalyzed Addition and Coupling Reaction of Aryl Triflates to Aldehydes

Zhang Mingdi, Chen Bin, Ge Chen, Liu Renrong, Gao Jianrong, Jia Yixia   

  1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2016-02-03 Revised:2016-03-09 Published:2016-03-18
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21372202) and the Program for New Century Excellent Talents in University (No. NCET-12-1086).

对芳基三氟甲磺酸酯对醛的加成或偶联反应进行了研究. 以Ni(dppe)Br2为催化剂,在锌粉存在下,芳基三氟甲磺酸酯与醛在甲醇溶剂中发生加成反应,在四氢呋喃中发生偶联反应,分别以中等到良好的收率获得芳基甲醇化合物或芳基甲酮化合物.

关键词: 过渡金属催化, 芳基三氟甲磺酸酯, 加成反应, 偶联反应

The nickel-catalyzed addition and coupling reaction between aryl triflates and aldehydes were developed. The reactions proceed smoothly in the presence of zinc powder with the use of 10 mol% Ni(dppe)Br2 as a catalyst. A range of aryl methanols and aryl ketones were isolated respectively in moderate to good yields in MeOH and THF solvent via direct addition or coupling reactions. Aliphatic and aromatic aldehydes were involved in this reaction, showing a broad substrate scope.

Key words: transition-metal catalysis, aryl triflate, addition reaction, coupling reaction