有机化学 ›› 2016, Vol. 36 ›› Issue (9): 2232-2235.DOI: 10.6023/cjoc201603044 上一篇    下一篇

研究简报

异丙醇还原法制备甲基异丁基酮的研究

徐林a,b,c, 王芳d, 黄杰军b, 徐清b,c, 俞磊a,b,c, 范以宁a   

  1. a 南京大学化学化工学院 南京 210093;
    b 江苏扬农化工集团有限公司 扬州 225009;
    c 扬州大学化学化工学院 扬州 225002;
    d 扬州工业职业技术学院 扬州 225127
  • 收稿日期:2016-03-28 修回日期:2016-04-20 发布日期:2016-05-17
  • 通讯作者: 俞磊, 范以宁 E-mail:yulei@yzu.edu.cn;ynfan@nju.edu.cn
  • 基金资助:

    国家自然科学基金(No.21202141)、浙江省自然科学杰出青年基金(No.LR14B020002)、江苏省高校优势学科项目、扬州市自然科学基金重大科技专项(No.YZ20122029)、扬州大学高端人才支持计划资助项目.

Investigation on Preparation of Methyl Isobutyl Ketone through the Reduction by Isopropanol

Xu Lina,b,c, Wang Fangd, Huang Jiejunb, Xu Qingb,c, Yu Leia,b,c, Fan Yininga   

  1. a School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093;
    b Jiangsu Yangnong Chemical Group Co. Ltd., Yangzhou 225009;
    c School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002;
    d Yangzhou Polytechnology Institute, Yangzhou 225127
  • Received:2016-03-28 Revised:2016-04-20 Published:2016-05-17
  • Supported by:

    Project supported by the National Natural Science Fundation of China (No.21202141), the Zhejiang Natural Science Foundation for Distinguished Young Scholars (No.LR14B020002), the Priority Academic Program Development of Jiangsu Higher Education Institutions, the Key Science & Technology Specific Projects of Yangzhou (No.YZ20122029), and the High Level Talent Support Project of Yangzhou University.

目前,国内丙酮产能过剩.将丙酮转化为市场需求较大的高附加值产品,具有实际的应用价值.甲基异丁基酮(MIBK)是重要的工业中间体,有广泛的用途和广阔的市场.因此,利用丙酮为原料合成甲基异丁基酮,有巨大的工业应用前景.报道了以丙酮为原料,通过缩合、还原等步骤合成MIBK的简便方法.与传统方法不同之处在于,该方法中还原丙酮缩合产物异丙叉丙酮(MO)时,并不使用较危险的氢气,而使用异丙醇作还原剂.还原剂氧化后产生的副产物丙酮可重新回收利用.通过反应条件的优化,可将MO转化率提高到95.8%,MIBK选择性达98.8%.反应还可以通过一锅两步法进行.

关键词: 丙酮, 异丙叉丙酮, 催化, 还原, 甲基异丁基酮

The production capacity of acetone is excess in China at present. Conversion of acetone into high-value products with huge market demands is of practical value. Methyl isobutyl ketone (MIBK) is an important industrial intermediate with very broad applications and large market requirement. Thus, there are tremendous prospects for industrial applications for the synthesis of MIBK from acetone. This article reports a convenient access to MIBK from acetone through condensation and reduction procedures. Compared with conventional procedures, the method employed isopropanol as an alternative reductant to the dangerous H2 to reduce mesityl oxide (MO) into MIBK. The by-product from the reductant isopropanol was acetone and could be reused as the starting material to produce MO. After conditional optimizations, the MO conversion rate was enhanced to 95.8%, while the selectivity of MIBK was 98.8%. The two steps of reaction could be performed in one-pot.

Key words: Acetone, mesityl oxide (MO), catalysis, reduction, methyl isobutyl ketone (MIBK)