有机化学 ›› 2017, Vol. 37 ›› Issue (3): 746-752.DOI: 10.6023/cjoc201607010 上一篇    下一篇

研究简报

碱促进下碳二亚胺参与构建二氢喹唑啉及其衍生物

汤玲娟a,b, 陆新谋b, 纪顺俊b   

  1. a 南通大学分析测试中心 南通 226019;
    b 江苏省有机合成重点实验室 苏州大学材料与化学化工学部 苏州 215123
  • 收稿日期:2016-07-05 修回日期:2016-10-19 发布日期:2016-12-12
  • 通讯作者: 纪顺俊,E-mail:shunjun@suda.edu.cn E-mail:shunjun@suda.edu.cn
  • 基金资助:

    国家自科学然基金(No.21372174)、江苏省高校优势学科建设工程资助项目.

Base Promoted Annulation of Carbodiimides to Access of Quinazoline and Their Derivatives

Tang Lingjuana,b, Lu Xinmoub, Ji Shunjunb   

  1. a Analysis and Testing Center, Nantong University, Suzhou 226019;
    b Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123
  • Received:2016-07-05 Revised:2016-10-19 Published:2016-12-12
  • Contact: 10.6023/cjoc201607010 E-mail:shunjun@suda.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21372174, 21542015), the Priority Academic Program Development of Jiangsu Higher Education Institutions.

发展了一种由含碳二亚胺结构的α,β-不饱和酮/酯和醇类化合物合成一系列具有潜在生理和药理活性的2-乙氧基-3-苯基-3,4-二氢喹唑啉杂环化合物的方法.反应条件温和、耗时短,且为无金属催化反应,反应收率最高可以达到99%.这为进一步构建喹唑啉这类含氮杂环化合物提供了一种有益策略.

关键词: 碳二亚胺, α,β-不饱和酮/酯, 喹唑啉, 无金属催化

An efficient methodology to access of quinazoline derivatives by the reaction of carbodiimides and alcohol under basic conditions has been developed. This paper provides an attractive strategy for construction of the quinazoline compounds and other heterocyclic compounds in a high reaction yield by using simple starting materials in mild reaction conditions and short reaction time.

Key words: carbodiimides, α,β-unsaturated ketone, quinazoline and their derivatives, metal-free