锰促进α-溴代酮与磺酰氯的还原偶联反应合成β-酮砜

doi:10.6023/cjoc201710027

有机化学 ›› 2018, Vol. 38 ›› Issue (4): 963-968.DOI: 10.6023/cjoc201710027 上一篇下一篇

研究简报

锰促进α-溴代酮与磺酰氯的还原偶联反应合成β-酮砜

陈震^a, 郭康^b, 陈荣顺^b, 顾晨^b, 周华婷^b, 朱映光^b

a 泰山医学院化学与制药工程学院泰安 271016;
b 南京农业大学理学院化学系江苏省农药学重点实验室南京 210095

收稿日期:2017-10-23 修回日期:2017-12-01 发布日期:2017-12-08
通讯作者: 陈荣顺, 朱映光 E-mail:rongshunchen@njau.edu.cn;ygzhu@njau.edu.cn
基金资助:
江苏省自然科学基金（No.BK20150652）、国家自然科学基金（No.21502096）、中央高校基本科研业务费专项资金（No.KJQN201629）、江苏省“333高层次人才培养工程”资助项目.

Facile Access to β-Ketosulfones via Mn-Mediated Reductive Coupling of α-Bromoketones with Sulfonyl Chlorides

Chen Zhen^a, Guo Kang^b, Chen Rongshun^b, Gu Chen^b, Zhou Huating^b, Zhu Yingguang^b

a School of Chemistry and Pharmaceutical Engineering, Taishan Medical University, Tai'an 271016;
b Jiangsu Key Laboratory of Pesticide Science and Department of Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing 210095

Received:2017-10-23 Revised:2017-12-01 Published:2017-12-08
Contact: 10.6023/cjoc201710027 E-mail:rongshunchen@njau.edu.cn;ygzhu@njau.edu.cn
Supported by:
Project supported by the Natural Science Foundation of Jiangsu Province (No. BK20150652), the National Natural Science Foundation of China (No. 21502096), the Fundamental Research Funds for the Central Universities (No. KJQN201629), and "333 High Level Talent Project" of Jiangsu Province.

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1. 锰促进α-溴代酮与磺酰氯的还原偶联反应合成β-酮砜.PDF(1531KB)

摘要/Abstract

从α-溴代酮与磺酰氯出发，发展了一种高效的还原偶联反应.在温和的条件下，能以良好到优秀的收率得到结构多样的β-酮砜类化合物.该方法实用且操作简单，无需严格去除空气和水，能放大到克级规模.

关键词: β-酮砜, α-溴代酮, 磺酰氯, 还原偶联, 锰

A mild and highly efficient reductive coupling of α-bromoketones with sulfonyl chlorides is described. Various β-ketosulfones can be obtained under mild conditions in good to excellent yields. This method provides a simple and practical access to β-ketosulfones and is amenable to gram scale with no special precautions to exclude air or moisture.

Key words: β-ketosulfones, α-bromoketones, sulfonyl chlorides, reductive coupling, manganese

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陈震, 郭康, 陈荣顺, 顾晨, 周华婷, 朱映光. 锰促进α-溴代酮与磺酰氯的还原偶联反应合成β-酮砜[J]. 有机化学, 2018, 38(4): 963-968.

Chen Zhen, Guo Kang, Chen Rongshun, Gu Chen, Zhou Huating, Zhu Yingguang. Facile Access to β-Ketosulfones via Mn-Mediated Reductive Coupling of α-Bromoketones with Sulfonyl Chlorides[J]. Chin. J. Org. Chem., 2018, 38(4): 963-968.

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锰促进α-溴代酮与磺酰氯的还原偶联反应合成β-酮砜

Facile Access to β-Ketosulfones via Mn-Mediated Reductive Coupling of α-Bromoketones with Sulfonyl Chlorides

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