亚氨基砜衍生物的合成研究进展(封面文章)

doi:10.6023/cjoc201710002

摘要/Abstract

亚氨基砜系列化合物具有广泛的生物或药物活性.近年来，在过渡金属催化下，亚氨基砜系列化合物的合成取得了长足的进展.直接以NH-亚氨基砜作为反应底物，可实现N-H键的直接官能团化反应，如炔基化、烯基化、烷基化、芳基化等等.此外，利用S=NH结构片段作为分子内的导向基团，还可以实现底物分子内芳香环的C（sp²）-H活化反应，合成结构各异的芳（杂）环衍生物.综述了亚氨基砜化合物N-H官能化反应和C-H官能化反应，并对部分反应的机理进行了讨论.

关键词: NH-亚氨基砜, 过渡金属催化, C-H官能化反应

The sulfoximine derivatives are widely known for their potent biological and medicinal activities. Recently, due to the transition-metal catalysis, great advancements have been achieved in the synthesis of sulfoximine derivatives. Utilizing free NH-sulfoximines as the starting materials, various the direct N-H functionalizations can be accomplished, such as alkynylation, alkenylation, alkylation, arylation, etc. In addition, the ortho arene C(sp²)-H activation can also be obtained through C-H activation reaction with the assistance of S=NH as intramolecular directing groups, thus giving varies (hetero)aromatic molecules. N-H and C-H functionalization reactions of sulfoximines were summarized, and the mechanisms of some novel model reactions are also briefly discussed.

Key words: NH-sulfoximine, transition-metal-catalysis, C-H functionalization

引用此文

周豪, 陈知远. 亚氨基砜衍生物的合成研究进展(封面文章)[J]. 有机化学, 2018, 38(4): 719-737.

Zhou Hao, Chen Zhiyuan. Recent Achievements in the Synthesis of Sulfoximine Derivatives[J]. Chin. J. Org. Chem., 2018, 38(4): 719-737.

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