Pd催化C(sp3)—H键活化构建杂环化合物的研究进展

doi:10.6023/cjoc201805028

摘要/Abstract

杂环类化合物是传统有机合成、农药和医药合成的重要中间体，也是构建若干具有生物活性天然产物的基本骨架.通过Pd催化的C（sp³）-H键活化实现一系列杂环化合物的合成，由于其具有高原子经济性的特点，近些年已发展成为杂环化合物合成领域的研究热点之一.根据所形成杂环化合物（主要涉及N、O杂环）的环数分类，综述了近十几年Pd催化C（sp³）-H键活化构建杂环化合物的研究进展，探讨了反应的选择性、底物兼容性和反应机理，并对该领域的现存局限性和发展前景进行了总结和展望.

关键词: Pd催化, C(sp³)-H键活化, 杂环

Heterocyclic compounds are not only important intermediates in organic synthesis and medicine synthesis, but also the basic building framework of biologically active natural products. In recent years, Pd-catalyzed C(sp³)-H bonds activation has been demonstrated as one of the hot topics in the field of heterocyclic compound synthesis because of its high atomic economic characteristics. Herein, the recent research progress in the construction of heterocyclic compounds via Pd-catalyzed C(sp³)-H bond activation is summarized according to the classification of the ring number of heterocyclic compounds (mainly including N, O heterocycles). The reaction selectivity, substrate compatibility, reaction mechanism, advantages and disadvantages as well as an outlook in this field are also discussed.

Key words: Pd-catalyzed, C (sp³)-H bond activation, heterocyclic compounds

引用此文

赵康, 杨磊, 刘建华, 夏春谷. Pd催化C(sp³)—H键活化构建杂环化合物的研究进展[J]. 有机化学, 2018, 38(11): 2833-2857.

Zhao Kang, Yang Lei, Liu Jianhua, Xia Chungu. Recent Advances in the Synthesis of Heterocyclic Compounds via Pd-Catalyzed C(sp³)-H Bond Activation[J]. Chin. J. Org. Chem., 2018, 38(11): 2833-2857.

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Pd催化C(sp³)—H键活化构建杂环化合物的研究进展

Recent Advances in the Synthesis of Heterocyclic Compounds via Pd-Catalyzed C(sp³)-H Bond Activation

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