有机化学 ›› 2019, Vol. 39 ›› Issue (5): 1469-1474.DOI: 10.6023/cjoc201812046 上一篇    下一篇

研究简报

锌-脯氨酸复合物催化的水相Knoevenagel缩合

颜世强a,b, 郭伟b, 王文笙b, 张伟a   

  1. a 复旦大学药学院 上海 201203;
    b 山东达因海洋生物制药股份有限公司 威海 264300
  • 收稿日期:2018-12-26 修回日期:2019-01-16 发布日期:2019-01-31
  • 通讯作者: 张伟 E-mail:zhangw416@fudan.edu.cn
  • 基金资助:

    国家自然科学基金(No.81573340)及山东省自主创新及成果转化专项(No.2015ZDXX0302A02)资助项目.

Zinc-Proline Complex Catalyzed Knoevenagel Condensation in Water

Yan Shiqianga,b, Guo Weib, Wang Wenshengb, Zhang Weia   

  1. a School of Pharmacy, Fudan University, Shanghai 201203;
    b Shandong Dyne Marine Biopharmaceutical Co., Ltd., Weihai 264300
  • Received:2018-12-26 Revised:2019-01-16 Published:2019-01-31
  • Contact: 10.6023/cjoc201812046 E-mail:zhangw416@fudan.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 81573340) and the Special Projects for Independent Innovation and Achievement Transformation of Shandong Province (No. 2015ZDXX0302A02).

报道了锌-脯氨酸复合物催化下的水相Knoevenagel缩合反应.17种芳香醛以及2种脂肪环酮与丙二腈在80℃下反应5~10 min,能够以84%~99%的收率得到相应的Knoevenagel缩合产物.催化剂回收重复使用10次,其催化活性不受影响.

关键词: Knoevenagel缩合, 水相反应, 锌-脯氨酸复合物, 环境友好

Zinc-proline complex catalyzed Knoevenagel condensation in water was reported. Seventeen aldehydes and two ketones were investigated, which coupled with malononitrile smoothly affording desired Knoevenagel condensation products in 5~10 min at 80℃ in the yields of 84%~99%. The catalyst can be recovered and reused for ten cycles without loss of activity.

Key words: Knoevenagel condensation, aqueous media, zinc-proline complex, environmentally benign