有机化学 ›› 2020, Vol. 40 ›› Issue (3): 625-644.DOI: 10.6023/cjoc201909015 上一篇    下一篇

综述与进展

配体促进的过渡金属催化芳烃远程meta-C—H键官能化反应研究进展

田万发b, 李娜a, 彭子赫c, 冯丽华a, 麦曦a, 贺永勤a   

  1. a 南昌大学药学院 南昌 330000;
    b 江西科技师范大学 有机功能分子重点实验室 南昌 330000;
    c 南昌大学抚州医学院 江西抚州 344000
  • 收稿日期:2019-09-09 修回日期:2019-11-27 发布日期:2019-12-19
  • 通讯作者: 贺永勤 E-mail:heyq12@lzu.edu.cn
  • 基金资助:
    国家自然科学基金(No.81860610)和南昌大学医学部青年教师培育基金(No.4209-16100009-PY201810)资助项目.

Recent Advances in Ligand-Promoted Transition-Metal-Catalyzed Remote meta-C—H Functionalization of Arenes

Tian Wanfab, Li Naa, Peng Zihec, Feng Lihuaa, Mai Xia, He Yongqina   

  1. a School of Pharmaceutical Science, Nanchang University, Nanchang 330000;
    b Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330000;
    c Fuzhou Medical College, Nanchang University, Fuzhou, Jiangxi 344000
  • Received:2019-09-09 Revised:2019-11-27 Published:2019-12-19
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 81860610) and the Young Teachers Training Foundation of Nanchang University (No. 4209-16100009-PY201810).

过渡金属催化C—H活化反应中,配体能够对催化中心的空间及电子效应进行调控,从而实现芳烃C—H键的选择性官能化.近年来,配体促进芳烃远程C—H键官能化反应研究有了新的进展.对近几年来配体促进的过渡金属催化芳烃远程meta-C—H键选择性官能化反应进行了系统总结,并对该研究领域的局限性和未来的发展前景进行总结和展望.

关键词: 过渡金属催化, 远程meta-C—H键, 官能化反应, 配体促进

Ligands can regulate both the steric and electronic effects of the catalytic center in transition-metal-catalyzed C-H activation reactions, leading to the site-selective C-H functionalization of arenes. In recent years, ligand-promoted remote C-H functionalization of arenes has developed rapidly. The recent progress on ligand-promoted transition-metal-catalyzed remote meta-selective C-H bond functionalization of arenes is summarized, and the limitations of the research field and prospects for future development are presented.

Key words: transition metal catalysis, remote meta-C—H bond, functionalization, ligand promotion