有机化学 ›› 2021, Vol. 41 ›› Issue (1): 412-417.DOI: 10.6023/cjoc202007028 上一篇    下一篇

研究简报

一种硫醚氧化为砜的绿色合成方法

方向a,*(), 王旺a, 杨雪艳a, 吴范宏b,*   

  1. a 华东理工大学化学与分子工程学院 上海 200237
    b 上海应用技术大学 上海绿色氟代制药工程技术研究中心 上海 201418
  • 收稿日期:2020-07-09 修回日期:2020-07-30 发布日期:2020-08-27
  • 通讯作者: 方向, 吴范宏
  • 作者简介:
    * Corresponding authors. E-mail:
  • 基金资助:
    国家自然科学基金(21672151)

A Green Method for the Synthesis of Sulfones from Thioethers

Xiang Fanga,*(), Wang Wanga, Xueyan Yanga, Fanhong Wub,*   

  1. a School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237
    b Shanghai Engineering Research Center of Green Fluoropharmaceutical Technology, Shanghai Institute of Technology, Shanghai 201418
  • Received:2020-07-09 Revised:2020-07-30 Published:2020-08-27
  • Contact: Xiang Fang, Fanhong Wu
  • Supported by:
    the National Natural Science Foundation of China(21672151)

硫醚在Selectfluor TM的作用下, 以水作为氧源得到相应砜类化合物, 最高收率可达99%. 在重氧水标记下, 得到 18O标记的甲基苯基砜产物. 本方法绿色环保, 条件温和, 并可放大至克量级规模.

关键词: 硫醚, SelecetfluorTM, 水, 砜类化合物

With water as oxygen source, a method for the synthesis of sulfones from thioethers under the action of Selecetfluor TM was designed. The yield can reach 99%. The 18O-labeled methylphenylsulfone was prepared with H2 18O. The conditions of this green method are mild and can reach the grams scale.

Key words: thioethers, SelecetfluorTM, water, sulfone compound