有机化学 ›› 2021, Vol. 41 ›› Issue (2): 529-542.DOI: 10.6023/cjoc202007007 上一篇    下一篇

综述与进展

氧气为唯一氧化剂的交叉脱氢偶联反应研究进展

庄伟辉a, 张晓凤a,*(), 黄秋锋a,b,*()   

  1. a 福建师范大学化学与材料学院 福州 350007
    b 福建省高分子材料重点实验室 福州 350007
  • 收稿日期:2020-07-02 修回日期:2020-08-23 发布日期:2020-10-28
  • 通讯作者: 张晓凤, 黄秋锋
  • 作者简介:
    * Corresponding authors. E-mail: ;
  • 基金资助:
    国家自然科学基金(21872028); 福建省教育厅青年重点基金(JZ160424); 福建省高校新世纪人才基金资助项目()

Recent Advances in Cross-Dehydrogenative-Coupling Reactions Using Molecular Oxygen as the Sole Oxidant

Weihui Zhuanga, Xiaofeng Zhanga,*(), Qiufeng Huanga,b,*()   

  1. a College of Chemistry & Materials Science, Fujian Normal University, Fuzhou 350007
    b Key Laboratory of Polymer Materials of Fujian Province, Fuzhou350007
  • Received:2020-07-02 Revised:2020-08-23 Published:2020-10-28
  • Contact: Xiaofeng Zhang, Qiufeng Huang
  • Supported by:
    the National Natural Science Foundation of China(21872028); the Foundation of Fujian Educational Committee(JZ160424); the Fujian Province University Fund for New Century Excellent Talents()

脱氢偶联反应是最有效、最直接的构建C—C键或C—杂键的一种方法. 但是目前大多数脱氢偶联反应需要使用化学计量的有毒氧化剂, 如PhI(OAc)2、苯醌、Cu(II)盐、有机过氧酸或Ag(I)盐等. 氧气廉价易得, 作为脱氢偶联反应中的唯一氧化剂, 副产物只有水, 不会产生其他有毒副产物, 是绿色环境友好的方法. 根据催化剂的分类, 综述了氧气作为唯一氧化剂的交叉脱氢偶联反应研究进展.

关键词: 交叉脱氢偶联, 氧气, 唯一氧化剂

Cross-dehydrogenative-coupling (CDC) reactions have emerged as one of the most efficient and straightforward methods for the formation of C—C bonds or C-heteroatom bonds. However, most CDC reactions require hazardous and stoichiometric oxidants, such as PhI(OAc)2, benzoquinone, copper(II) salts, organic peroxide acid and silver(I) salts. A green and environmentary benign approach is using molecular oxygen (O2) as oxidant in the reactions, which usually form water as by-product. According to the classification of catalysts, the research progress of cross dehydrogenation coupling reaction with oxygen as the only oxidant is reviewed.

Key words: cross-dehydrogenative-coupling, molecular oxygen, oxidant