有机化学 ›› 2021, Vol. 41 ›› Issue (8): 2990-3001.DOI: 10.6023/cjoc202103013 上一篇    下一篇

综述与进展

过渡金属催化氮原子导向的芳基邻位C—H键硼化反应研究进展

罗欢欢, 裴娜, 张敬*()   

  1. 武汉大学高等研究院 武汉 430000
  • 收稿日期:2021-03-06 修回日期:2021-04-02 发布日期:2021-05-08
  • 通讯作者: 张敬
  • 基金资助:
    中央高校基本科研业务费专项资金(2042019kf0008)

Advances in Nitrogen-Directed Aromatic Compound ortho-C—H Bond Borylation Catalyzed by Transition Metals

Huanhuan Luo, Na Pei, Jing Zhang()   

  1. Institute for Advanced Studies, Wuhan University, Wuhan 430000
  • Received:2021-03-06 Revised:2021-04-02 Published:2021-05-08
  • Contact: Jing Zhang
  • Supported by:
    Fundamental Research Funds for the Central Universities(2042019kf0008)

芳基硼化合物在合成化学、材料化学和生物医学领域都有着广泛的应用, 其合成方法一直是有机合成领域中的研究热点. 导向基团辅助过渡金属催化的C—H键硼化反应具有步骤经济性, 底物多样性, 高区域选择性的优点. 其中含氮原子导向基团底物的硼化反应引起了学者们的兴趣, 因为N, C螯合的四配位有机硼化物是重要的光电材料. 按照不同过渡金属(铱、铑、钯、钌)总结了近年来含氮原子导向的芳香化合物邻位C—H键硼化反应的进展.

关键词: 邻位C—H键活化, 硼化, 氮原子导向, 过渡金属催化

Aromatic boron compounds have been widely used in synthetic chemistry, materials and medicinals, and developing new methods for their synthesis has been a hot topic. Directing groups assisted C—H bond borylation catalyzed by transition metal has significant advantages in step-economy, substrates diversity and high regio-selectivity. The borylation of nitrogen-based substrates has attracted interest from researchers, because four-coordinated organoboron compounds chelated by N,C are important photoelectric materials. In this paper, the preparation of aromatic boron compounds from ortho-C—H bond borylation catalyzed by Ir, Rh, Ru, Pd assisting by directing groups containing nitrogen atoms is summarized.

Key words: ortho-C—H activation, borylation, nitrogen-directed, transition metal catalyze