有机化学 ›› 2022, Vol. 42 ›› Issue (10): 3051-3101.DOI: 10.6023/cjoc202206028 上一篇    下一篇

所属专题: 不对称催化专辑

综述与进展

过渡金属催化的烯/炔丙基杂原子偶极前体参与的不对称环化反应

张键a,b, 陈颖b, 汪全南a, 沈佳欢b, 刘飏子a,*(), 邓卫平a,b,*()   

  1. a 浙江师范大学化学与生命科学学院 浙江金华 321004
    b 华东理工大学药学院 上海 200237
  • 收稿日期:2022-06-17 修回日期:2022-07-07 发布日期:2022-11-02
  • 通讯作者: 刘飏子, 邓卫平
  • 作者简介:
    †共同第一作者
  • 基金资助:
    国家自然科学基金(21971062); 国家自然科学基金(22171082)

Transition Metal-Catalyzed Asymmetric Cyclizations Involving Allyl or Propargyl Heteroatom-Dipole Precursors

Jian Zhanga,b, Ying Chenb, Quannan Wanga, Jiahuan Shenb, Yangzi Liua(), Weiping Denga,b()   

  1. a College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004
    b School of Pharmacy, East China University of Science and Technology, Shanghai 200237
  • Received:2022-06-17 Revised:2022-07-07 Published:2022-11-02
  • Contact: Yangzi Liu, Weiping Deng
  • About author:
    †These authors contributed equally to this work.
  • Supported by:
    National Natural Science Foundation of China(21971062); National Natural Science Foundation of China(22171082)

手性杂环化合物是一类重要的手性物质, 存在于许多手性药物、农药及催化剂中, 实现其催化不对称合成一直是有机合成的研究热点. 而过渡金属催化的杂原子偶极参与的不对称环化反应是构建该骨架的重要方法. 其中, 基于过渡金属催化的烯/炔丙基取代反应设计的杂原子偶极前体在近二十年来发展迅速, 在该领域占有着重要地位. 详细介绍了烯/炔丙基杂原子偶极前体参与的过渡金属催化不对称环化反应, 分析了目前方法的优势及存在的问题, 以期为从事催化不对称合成及相关领域的研究者提供有益借鉴和参考.

关键词: 过渡金属催化, 杂原子偶极, 不对称环化

Chiral heterocyclic compounds are an important class of chiral substances, which are widespread in many chiral drugs, pesticides and catalysts. Therefore, the efficient asymmetric synthesis of these compounds becomes a research hotspot in organic synthesis. Transition metal-catalyzed asymmetric cyclization with heteroatom-dipole precursors is an important method to construct these frameworks. Among them, the heteroatom-dipole precursors designed based on transition metal-catalyzed allyl or propargyl substitutions have been extensively studied in the past two decades and occupied an important role in this field. The transition metal-catalyzed asymmetric cyclizations with allyl or propargyl heteroatom-dipole precursors are introduced in detail. The advantages and existing problems of the current methods are analyzed, which would provide useful reference for the researchers in asymmetric synthesis and related fields.

Key words: transition metal catalysis, heteroatom dipole, asymmetric cyclization