有机化学 ›› 2024, Vol. 44 ›› Issue (3): 728-747.DOI: 10.6023/cjoc202311032 上一篇    下一篇

综述与进展

氧化型光电催化促进的C—H键官能团化反应研究进展

Hasil Aman, 常瑞, 叶俊涛*()   

  1. 上海交通大学化学化工学院 上海市手性药物分子工程重点实验室 上海 200240
  • 收稿日期:2023-11-30 修回日期:2024-01-30 发布日期:2024-04-02
  • 基金资助:
    国家自然科学基金(22371180); 国家自然科学基金(22001163)

Recent Advances on C—H Functionalization via Oxidative Electrophotocatalysis

Aman Hasil, Rui Chang, Juntao Ye()   

  1. Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240
  • Received:2023-11-30 Revised:2024-01-30 Published:2024-04-02
  • Contact: *E-mail: juntaoye@sjtu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(22371180); National Natural Science Foundation of China(22001163)

惰性C—H键直接选择性官能团化反应是有机合成领域长久以来的挑战之一. 虽然已经发展了多种策略, 但仍亟待发展无需添加过渡金属和氧化剂的新方法. 近年来, 光电催化作为一种新兴策略, 能够在温和条件下实现包括直接C—H键官能团化在内的多种挑战性转化反应, 表现出强大的潜力. 从机理的角度出发, 总结了通过阳极氧化的光电催化策略实现C—H键官能团化反应的最新研究进展, 并简单讨论了这个新兴领域所面临的挑战和机遇.

关键词: 光电催化, 电化学, C—H键官能团化, 氧化反应

Direct and selective functionalization of relatively inert C—H bonds is a long-standing challenge in synthetic chemistry. While many strategies have been developed to date, new approach that does not require the use of transition-metals and oxidants is in high demand. Recently, electrophotocatalysis has emerged as a powerful means to effect direct C—H functionalization and other types of challenging transformations under mild reaction conditions. The recent advances on electrophotocatalytic C—H functionalization via anode oxidation are highlighted with a focus on mechanistic aspects. Challenges and opportunities of this emerging field are also discussed.

Key words: electrophotocatalysis, electrochemistry, C—H functionalization, oxidation