二萜生物碱全合成研究新进展

doi:10.6023/cjoc202408012

摘要/Abstract

二萜生物碱是一类具有复杂化学结构和丰富生物活性的天然产物. 长期以来, 二萜生物碱独特的笼状骨架、多立体手性中心和稠密的含氧取代基团使其成为天然产物全合成领域的挑战性目标分子. 近五年, 该领域的研究取得了显著进展. 本文综述了2020年至今报道的二萜生物碱全合成工作, 重点介绍创新合成方法和策略的发展与应用.

关键词: 二萜生物碱, 天然产物, 全合成, 合成方法与策略

Diterpenoid alkaloids are a family of natural products with complex chemical structures and a rich array of biological activities. Their unique cage-like skeletons, multiple stereogenic chiral centers, and densely oxygenated substituents have long rendered them challenging target molecules in the field of natural product total synthesis. In the past five years, significant progress has been made in this research area. This article reviews the total synthesis of diterpenoid alkaloids reported from 2020 to the present, focusing on the development and application of innovative synthetic methods and strategies.

Key words: diterpenoid alkaloid, natural product, total synthesis, synthetic method and strategy

引用此文

李闯, 张成, 刘小宇, 秦勇. 二萜生物碱全合成研究新进展[J]. 有机化学, doi: 10.6023/cjoc202408012.

Li Chuang, Zhang Cheng, Liu Xiao-Yu, Qin Yong. Recent Progress in the Total Synthesis of Diterpenoid Alkaloids[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202408012.

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