无添加剂条件下硫叶立德与硫代羧酸硫酯化反应合成β-羰基硫代羧酸酯

doi:10.6023/cjoc202507031

研究论文

无添加剂条件下硫叶立德与硫代羧酸硫酯化反应合成β-羰基硫代羧酸酯

杨梓^a,*, 马超^b, 王祖利^d, 魏伟^b,*, 易东^c,*

^a长沙医科大学功能核酸基础与临床湖南省普通高校重点实验室长沙 410219;
^b曲阜师范大学化学与化工学院曲阜 273165;
^c西南医科大学药学院泸州 646000;
^d南京林业大学林木生物质低碳高效利用国家工程研究中心南京 210037

收稿日期:2025-07-21 修回日期:2025-09-08
基金资助:
泸州市人民政府西南医科大学科技战略合作项目 (2023LZXNYDJ019).

Additive-Free Synthesis of β-Keto thioesters through Thiocarbonylation of Sulfoxonium Ylides with Thioic acids

Yang Zi^a,*, Ma Chao^b, Wang Zu-Li^d, Wei Wei^b,*, Yi Dong^c,*

^aHunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha 410219;
^bSchool of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165;
^cSchool of Pharmacy, Southwest Medical University, Luzhou 646000;
^dNational Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass, Nanjing Forestry University, Nanjing 210037

Received:2025-07-21 Revised:2025-09-08
Contact: *E-mail: yangziycy@163.com; weiweiqfnu@163.com; yidong@swmu.edu.cn
Supported by:
Science and Technology Strategic Cooperation Programs of Luzhou Municipal People's Government and Southwest Medical University (2023LZXNYDJ019).

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摘要/Abstract

报道了一种简单、便利的硫叶立德与硫代羧酸的硫酯化反应合成β-羰基硫代羧酸酯的方法. 多种β-羰基硫代羧酸酯能够在室温和无添加剂条件下获得中等至良好收率. 该反应能进行克级规模实验,拥有操作便利、条件温和以及无金属污染的优势.

关键词: 硫叶立德, 硫代羧酸, β-羰基硫代羧酸酯, 无添加剂

A simple and convenient strategy for the synthesis of β-keto thioesters has been developed through the thiocarbonylation reaction of sulfoxonium ylides with thioic acids. A number of β-keto thioestrs could be efficiently obtained at room temperature with moderate to good yields in the absence of any additives. The reaction could be easily scaled up, which features operational simplicity, mild condition, and good reaction efficiency.

Key words: Sulfoxonium Ylides, Thioic acids, β-Keto thioesters, Additive-free

引用此文

杨梓, 马超, 王祖利, 魏伟, 易东. 无添加剂条件下硫叶立德与硫代羧酸硫酯化反应合成β-羰基硫代羧酸酯[J]. 有机化学, doi: 10.6023/cjoc202507031.

Yang Zi, Ma Chao, Wang Zu-Li, Wei Wei, Yi Dong. Additive-Free Synthesis of β-Keto thioesters through Thiocarbonylation of Sulfoxonium Ylides with Thioic acids[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202507031.

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