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研究论文

可见光促进通过氢原子转移合成1,4-二羰基衍生物

吴志杰, 周超*, 李金山, 徐佳欣, 张义成, 刘杰*, 王磊*   

  1. 淮北师范大学绿色和精准合成化学及应用教育部重点实验室,化学与化工学院 安徽淮北 235000
  • 收稿日期:2026-01-23 修回日期:2026-04-01

Visible-Light-Induced Synthesis of 1,4-Dicarbonyl Derivatives via Hydrogen Atom Transfer Process

Zhijie Wu, Chao Zhou*, Jinshan Li, Jiaxin Xu, Yicheng Zhang, Jie Liu*, Lei Wang*   

  1. Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, School of Chemistry and Chemical Engineering, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China
  • Received:2026-01-23 Revised:2026-04-01
  • Contact: *E-mail: leiwang@chnu.edu.cn; zhouc@chnu.edu.cn
  • Supported by:
    National Natural Science Foundation of China (22471187), Shanghai Wencai New Materials Technology (22100424/2025340603000216), Natural Science Research Key Project of Anhui Province (2025AHGXZK30556) and Research Fund of Excellent Young Scientists in Higher Education Institution of Anhui Province, China (2022AH030060).

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本文发展了一种可见光诱导下通过氢原子转移 (Hydrogen Atom Transfer, HAT) 过程合成1,4-二羰基化合物的新方法。该方法具有原料易得、底物适用范围广、反应条件温和及产率优良等优点,为1,4-二羰基类化合物的高效构建提供了一种绿色、便捷的合成策略。此外,克量级反应的成功实施,以及产物进一步转化为多种杂环衍生物,体现了该方法的实用价值。

关键词: 可见光, 氢原子转移, 自由基, 1,4-二羰基化合物

This work reports a novel visible-light-promoted synthesis of 1,4-dicarbonyl compounds via a hydrogen atom transfer (HAT) process. This method employs readily available starting materials, exhibits broad substrate compatibility, proceeds under mild conditions, and delivers products in good to excellent yields, thereby offering an efficient and practical strategy for accessing this important class of compounds. Moreover, the successful execution of gram-scale reactions and the subsequent transformation of the products into various heterocyclic derivatives underscore its significant synthetic potential.

Key words: Visible-light, Hydrogen atom transfer (HAT) process, Radical reaction, 1,4-Dicarbonyl compounds