Zirconocene Bis(perfluorooctanesulfonate)s-Catalyzed the Reaction of Indoles and Carbonyl Compounds

doi:10.6023/cjoc201207017

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (12): 2390-2393.DOI: 10.6023/cjoc201207017 Previous Articles Next Articles

Notes

全氟辛基磺酸茂锆催化吲哚与羰基化合物反应

易卫国^a,b, 贾振永^b, 李宁波^b, 邱仁华^b, 陈锦杨^b, 许新华^b

a 湖南化工职业技术学院株洲 412004;
b 湖南大学化学化工学院长沙 410082

收稿日期:2012-07-12 修回日期:2012-08-06 发布日期:2012-08-10
通讯作者: 许新华 E-mail:xhx1581@yahoo.com.cn
基金资助:
国家自然科学基金(Nos. 21172061, 21273068)资助项目.

Zirconocene Bis(perfluorooctanesulfonate)s-Catalyzed the Reaction of Indoles and Carbonyl Compounds

Yi Weiguo^a,b, Jia Zhenyong^b, Li Ningbo^b, Qiu Renhua^b, Chen Jinyang^b, Xu Xinhua^b

a Hunan Chemical Industry Vocation Technology Institute, Zhuzhou 412004;
b College of Chemistry Chemical Engineering, Hunan University, Changsha 410082

Received:2012-07-12 Revised:2012-08-06 Published:2012-08-10
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21172061, 21273068).

In the presence of 1.0 mol% zirconocene bis(perfluorooctanesulfonate)s, indoles reacted with aldehyde/ketone at room temperature in tetrahydrofuran for 10～25 min to give diindolylmethane derivatives in 86%～96% yields. The catalyst zirconocene bis(perfluorooctanesulfonate)s can be reused 6 times, and the conversion rate is still as high as 90%. This reaction does not require strict anhydrous conditions. This procedure provides a new and efficient way for preparing diindolylmethane derivatives.

Key words: zirconocene bis(perfluorooctanesulfonate)s, catalysis, synthesis, diindolylmethane derivatives

Cite this article

Yi Weiguo, Jia Zhenyong, Li Ningbo, Qiu Renhua, Chen Jinyang, Xu Xinhua. Zirconocene Bis(perfluorooctanesulfonate)s-Catalyzed the Reaction of Indoles and Carbonyl Compounds[J]. Chin. J. Org. Chem., 2012, 32(12): 2390-2393.

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全氟辛基磺酸茂锆催化吲哚与羰基化合物反应

Zirconocene Bis(perfluorooctanesulfonate)s-Catalyzed the Reaction of Indoles and Carbonyl Compounds

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