Enantioselective Organocatalytic Intramolecular Friedel-Crafts Alkylations of Pyrrole-Type Aryloxy-and Arylamino-tethered Enals: Access to a New Class of Pyrrole-Fused Heterocycles

doi:10.6023/cjoc201707003

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3163-3169.DOI: 10.6023/cjoc201707003 Previous Articles Next Articles

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吡咯分子内的Friedel-Crafts烷基化关环反应:“一锅法”对映选择性地构建吡咯稠杂环类化合物

朱晓宇, 赵亚楠, 兰丽艳, 李文泽

沈阳化工大学应用化学学院沈阳 110142

收稿日期:2017-07-04 修回日期:2017-08-23 发布日期:2017-09-15
通讯作者: 李文泽 E-mail:liwenze@syuct.edu.cn
基金资助:
国家自然科学基金（No.21502118）资助项目.

Enantioselective Organocatalytic Intramolecular Friedel-Crafts Alkylations of Pyrrole-Type Aryloxy-and Arylamino-tethered Enals: Access to a New Class of Pyrrole-Fused Heterocycles

Zhu Xiaoyu, Zhao Yanan, Lan Liyan, Li Wenze

College of Applied Chemistry, Shenyang University of Chemical Technology, Shenyang 110142

Received:2017-07-04 Revised:2017-08-23 Published:2017-09-15
Contact: 10.6023/cjoc201707003 E-mail:liwenze@syuct.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21502118).

1. Enantioselective Organocatalytic Intramolecular Friedel-Crafts Alkylations of Pyrrole-Type Aryloxy-and Arylamino-tethered Enals: Access to a New Class of Pyrrole-Fused Heterocycles.PDF(1082KB)

Abstract

The catalytic asymmetric one-pot tandem intermolecular olefin cross-metathesis/intramolecular Friedel-Crafts alkylation with aryloxy-and arylamino-tethered enals as building blocks was developed, which offers a direct and convenient access to a novel type of pyrrole-fused heterocyclic compounds in good yields with synthetically useful enantioselectivities.

Key words: pyrrole-fused heterocycles, olefin cross-metathesis, Friedel-Crafts alkylation, asymmetric synthesis, one pot

Cite this article

Zhu Xiaoyu, Zhao Yanan, Lan Liyan, Li Wenze. Enantioselective Organocatalytic Intramolecular Friedel-Crafts Alkylations of Pyrrole-Type Aryloxy-and Arylamino-tethered Enals: Access to a New Class of Pyrrole-Fused Heterocycles[J]. Chin. J. Org. Chem., 2017, 37(12): 3163-3169.

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吡咯分子内的Friedel-Crafts烷基化关环反应:“一锅法”对映选择性地构建吡咯稠杂环类化合物

Enantioselective Organocatalytic Intramolecular Friedel-Crafts Alkylations of Pyrrole-Type Aryloxy-and Arylamino-tethered Enals: Access to a New Class of Pyrrole-Fused Heterocycles

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