Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (5): 1483-1488.DOI: 10.6023/cjoc201811034 Previous Articles     Next Articles

Special Issue: 荧光探针-生物传感合辑 有机超分子化学合辑



杨滋琦a, 刘兴坤b, 姜鲁南b, 王美a   

  1. a 河北大学化学与环境科学学院 保定 071002;
    b 河北大学药学院 保定 071002
  • 收稿日期:2018-11-28 修回日期:2019-01-07 发布日期:2019-01-18
  • 通讯作者: 王美
  • 基金资助:


Design, Synthesis and Application of Fluorescence Resonance Energy Transfer-Based Ratiometric Hydrazine Fluorescent Probe

Yang Ziqia, Liu Xingkunb, Jiang Lu'nanb, Wang Meia   

  1. a College of Chemistry and Environmental Science, Hebei University, Baoding 071002;
    b College of Pharmacy, Hebei University, Baoding 071002
  • Received:2018-11-28 Revised:2019-01-07 Published:2019-01-18
  • Contact: 10.6023/cjoc201811034
  • Supported by:

    Project supported by the National Natural Scinec Foundation of China (No. 51578067), the Natural Science Foundation of Hebei Provience (No. 2018201234), the Colleges and Universities Science Technology Research Project of Hebei Province (No. QN2017015) and the Science Technology Research and Development Guidance Programme Project of Baoding City (Nos. 16zg031, 18ZF315).

Hydrazine (N2H4) is a highly toxic biochemical reagent with the capability of mutagenic, teratogenic and carcinogenic. For accurately monitoring the concentration of N2H4 in the environment and life, two FRET (fluorescence resonance energy transfer)-based dual-emissive ratiometric fluorescent probes (FRET-1/2) were designed and synthesized. The structures of both probes were charactered by 1H NMR, 13C NMR and HRMS. The results prove that both probes exhibit good selectivity and sensitivity to N2H4 and can be used for detecting N2H4 in water samples.

Key words: hydrazine, fluorescence resonance energy transfer (FRET), ratiometric, fluorescent probe