Selective coupling reactions of Grignard reagents with acyl halides by copper complexes catalysis: Synthesis of straight chain ketones

Abstract

The selective coupling reactions of Grignard reagents with acyl chlorides and halo acyl chlorides catalyzed by some soluble copper complexes was reported. This is a convenient method for synthesis of straight chain aliphatic ketones and halo ketones. E.g., stirring hexanoyl chloride with pentylmagnesium bromide and Li2CuCl4 in THF for 8 h gave 80.6% 6-undecanone.

Key words: CATALYST, REACTION SELECTIVITY, COPPER COMPLEX, GRIGNARD REAGENT, ALIPHATIC KETONES, ACYL HALIDES, COUPLING REACTION

CLC Number:

O621

Cite this article

ZHANG HANCHENG;ZHANG JIAWANG;GUO QIZHEN. Selective coupling reactions of Grignard reagents with acyl halides by copper complexes catalysis: Synthesis of straight chain ketones[J]. Chin. J. Org. Chem., 1989, 9(1): 73-75.

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