Recently, as solution-phase asymmetric synthesis have been successfully carried out on solid phase, solid-phase asymmetric synthesis (SPAS) would become a powerful tool for generation of chiral small molecule libraries and total synthesis of natural products. In this paper, several approaches of SPAS (chiral substrate induction, chiral auxiliary induction, chiral reagent induction and chiral catalysis) and their application are reviewed.

Key words: INDUCTION, ORGANIC SYNTHESIS