In this article, O-diisoproppyloxyphosphoryl-L-serine, -threonine and -tyrosine were designed and synthesized. Among them, O-diisopropyloxyphosphoryl-L-serine or -threonine was obtained by the migration of phosphoryl group from nitrogen to oxygen of the corresponding N-diisopropyloxyphosphoryl-L-serine or -threonine under ultrasonic irradiation. N-Diisoproppyloxyphosphoryl-L-serine or -threonine was successfully prepared from diisopropyl phosphite and serine or threonine in sodium hypochlorite aqueous media in good yield. O-Diisopropyloxyphosphoryl-L-tyrosine was synthesized via reaction of L-tyrosine cupric complex with diisopropyl phosphorochloridate, then unprotection by sulfide hydrogen.

Key words: serine, threonine, tyrosine, phosphorylation, synthesis