Synthesis of 1,4,5,6,7,8-Hexahydroquinolin-5-one Derivatives under Solvent-Free Conditions without Using Any Catalysts

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (05): 837-840. Previous Articles Next Articles

Original Articles

无溶剂、无催化剂条件下合成1,4,5,6,7,8-六氢喹啉-5-酮衍生物

荣良策*^,a,b，韩红霞^a，姜虹^b，庄启亚^a，姚昌盛^a，屠树江^a,b

(^a徐州师范大学化学化工学院徐州 221116)
(^b江苏省药用植物生物技术重点实验室徐州 221116)

收稿日期:2007-06-20 修回日期:2007-08-24 发布日期:2008-05-20
通讯作者: 荣良策

Synthesis of 1,4,5,6,7,8-Hexahydroquinolin-5-one Derivatives under Solvent-Free Conditions without Using Any Catalysts

RONG Liang-Ce*^,a,b,HAN Hong-Xia^a,JIANG Hong^b,ZHUANG Qi-Ya^a
YAO Chang-Sheng^a,TU Shu-Jiang^a,b

(^aCollege of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116)
(^bKey Laboratory of Biotechnology for Medicinal Plant, Xuzhou 221116)

Received:2007-06-20 Revised:2007-08-24 Published:2008-05-20
Contact: RONG Liang-Ce

Abstract

Under solvent-free conditions, synthesis of 1,4,5,6,7,8-hexahydroquinolin-5-one derivatives from chalcones and 1,3-cyclohexanedione in the presence of NH₄OAc was carried out in excellent yields without using any catalysts. This method has the advantages of mild reaction conditions, simple protocol, and friendly environment. The structures of the products were confirmed on the basis of IR, ¹H NMR spectra, elemental analysis, and that of 3b was additionally confirmed by X-ray diffraction analysis.

Key words: chalcone, solvent-free, 1,4,5,6,7,8-hexahydroquinolin-4-one, synthesis, 1,3-cyclohexanedione

Cite this article

RONG Liang-Ce*^,a,b,HAN Hong-Xia^a,JIANG Hong^b,ZHUANG Qi-Ya^a
YAO Chang-Sheng^a,TU Shu-Jiang,b. Synthesis of 1,4,5,6,7,8-Hexahydroquinolin-5-one Derivatives under Solvent-Free Conditions without Using Any Catalysts[J]. Chin. J. Org. Chem., 2008, 28(05): 837-840.

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无溶剂、无催化剂条件下合成1,4,5,6,7,8-六氢喹啉-5-酮衍生物

Synthesis of 1,4,5,6,7,8-Hexahydroquinolin-5-one Derivatives under Solvent-Free Conditions without Using Any Catalysts

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