The Synthesis and Activities of 3a, 4-Dihydro chromeno [4, 3-c] pyrazol-3(2 H)-one derivatives

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (11): 1774-1783. Previous Articles Next Articles

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3a, 4-二氢-苯并吡喃[4,3-c]吡唑-3(2H)-酮类衍生物的合成及其活性

周中振^a,b 陈琼^*,a 杨光富^a

(a华中师范大学农药与化学生物学教育部重点实验室武汉 430079) (b南方医科大学药学院广州 510515)

收稿日期:2008-12-23 修回日期:2009-04-20 发布日期:2009-06-18
通讯作者: 陈琼 E-mail:qchen@mail.ccnu.edu.cn
基金资助:
国家级.国家自然科学基金

The Synthesis and Activities of 3a, 4-Dihydro chromeno [4, 3-c] pyrazol-3(2 H)-one derivatives

Zhou, Zhongzhen ^a,b Chen, Qiong^*,a Yang, Guangfu^a

(^a Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079) (^b School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515)

Received:2008-12-23 Revised:2009-04-20 Published:2009-06-18

Abstract

We designed and synthesized 33 novel 3a, 4-dihydro-3a-methyl- chromeno [4, 3-c] pyrazol- 3(2 H)-one derivatives. The structures of the target compounds were determined by means of MS, 1H NMR and elemental analysis. The crystal structure of the target compound 7k was determined by X-ray diffraction analysis. At the same time, preliminary bioassay showed that part of them had insecticidal activities and antibacterial activity.

Key words: 2,3a-dihydrochromeno[4,3-c]pyrazol-3-one, synthesis, insecticidal activity, fungicide activity

Cite this article

ZHOU Zhong-Zhen, CHEN Qiong, YANG Guang-Fu. The Synthesis and Activities of 3a, 4-Dihydro chromeno [4, 3-c] pyrazol-3(2 H)-one derivatives[J]. Chin. J. Org. Chem., 2009, 29(11): 1774-1783.

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3a, 4-二氢-苯并吡喃[4,3-c]吡唑-3(2H)-酮类衍生物的合成及其活性

The Synthesis and Activities of 3a, 4-Dihydro chromeno [4, 3-c] pyrazol-3(2 H)-one derivatives

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