Progress of Crystallization-Induced Asymmetric Transformation in Resolution of Chiral Compounds

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (07): 951-957. Previous Articles Next Articles

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结晶诱导不对称转化在拆分手性化合物中的研究进展

熊文说，王鸿，易喻，梅建凤，应国清*

(浙江工业大学药学院杭州 310014)

收稿日期:2009-08-31 修回日期:2010-10-20 发布日期:2009-12-30
通讯作者: 应国清 E-mail:bioph@zjut.edu.cn
基金资助:
浙江省新世纪151人才基金资助(No.06-2-104)

Progress of Crystallization-Induced Asymmetric Transformation in Resolution of Chiral Compounds

XIONG Wen-Shuo, WANG Hong, YI Yu, MEI Jian-Feng, YING Guo-Qing

(College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014)

Received:2009-08-31 Revised:2010-10-20 Published:2009-12-30

Abstract

Crystallization-induced dynamic resolution (CIDR) is a combination of racemization of enantiomers either as the free compounds or as diastereomeric salt with a chiral gegenion and selective crystallization. Crystallization-induced asymmetric transformation (CIAT) includes CIDR and other processes, which may include compounds with two or more diastereomeric centers and olefins. The progress of CIAT and CIDR in resolution of chiral compounds is summarized.

Key words: crystallization-induced dynamic resolution, crystallization-induced asymmetric transformation, chiral compound, resolution

CLC Number:

O621.3

Cite this article

XIONG Wen-Shuo, WANG Hong, YI Yu, MEI Jian-Feng, YING Guo-Qing. Progress of Crystallization-Induced Asymmetric Transformation in Resolution of Chiral Compounds[J]. Chin. J. Org. Chem., 2010, 30(07): 951-957.

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结晶诱导不对称转化在拆分手性化合物中的研究进展

Progress of Crystallization-Induced Asymmetric Transformation in Resolution of Chiral Compounds

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