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Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (08): 1255-1258. Previous Articles     Next Articles

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4-卤-5-(4-甲基-2H-1-苯并-2-吡喃酮-7-氧基)-2-取代-3(2H)-哒嗪酮衍生物的合成和生物活性研究

拜堃1，姚彩萍2，陈青2，沈忱2，裴文*,1   

  1. (1浙江工业大学化学工程与材料学院 杭州 310014)
    (2浙江工商大学应用化学系 杭州 310012)
  • 收稿日期:2009-11-20 修回日期:2010-03-30 发布日期:2010-04-09
  • 通讯作者: 裴文 E-mail:peiwen58@zjut.edu.cn

Synthesis and Bioactivity of 4-Halogen-5-[(4-methyl-2-oxo-2H-1-ben- zopyran-7-yl)oxy]-2-substituted-3(2H)-pyridazinone Deriva-tives

Bai Kun1 Yao Caiping2 Chen Qing2 Shen Chen2 Pei Wen*,1   

  1. (1 College of Chemical Engineering and Materials, Zhejiang University of Technology, Hangzhou 310014)
    (2 Department of Applied Chemistry, Zhejiang Gongshang Univer-sity, Hangzhou 310012)
  • Received:2009-11-20 Revised:2010-03-30 Published:2010-04-09
  • Contact: pei wen E-mail:peiwen58@zjut.edu.cn

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Pyridazinone fragments were introduced into coumarin derivatives by the condensation of 4,5-dihalogenpyridazinone with 7-hydroxy-4-methyl coumarin in CH3CN/K2CO3 at reflux. Eight new compounds of pyridazinone derivatives containing coumarin ring were designed and synthesized. The structures of the new compounds were identified by 1H NMR and MS techniques and elemental analysis. The preliminary bio-assay results showed that 4-chloro-5-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]-2- (4-nitro-phenyl)-3(2H)-pyridazinone possessed restraining cucumber cotyledon root-formation ac-tivity.

Key words: coumarin, pyridazinone, synthesis, biological activity