Synthesis of a New Biphenyl Diphosphine Ligand and Its Pd-Catalyzed Suzuki-Miyaura Reaction

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (10): 1529-1534. Previous Articles Next Articles

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新型联苯类双膦配体的合成及钯催化Suzuki-Miyaura反应

彭宗海¹，马梦林²，付海燕¹，陈华*^,1

(¹四川大学化学学院有机金属络合催化研究所绿色化学与技术教育部重点实验室成都 610064)
(²西华大学化学系成都 611930)

收稿日期:2010-02-26 修回日期:2010-05-06 发布日期:2010-06-03
通讯作者: 陈华 E-mail:scuhchen@163.com

Synthesis of a New Biphenyl Diphosphine Ligand and Its Pd-Catalyzed Suzuki-Miyaura Reaction

Peng Zonghai¹ Ma Menglin² Fu Haiyan¹ Chen Hua*^,1

(¹Key Laboratory of Green Chemistry and Technology, Ministry of Education, the Institute of Homogeneous Catalysis, Faculty of Chemistry, Sichuan University, Chengdu 610064)
(²Department of Chemistry, Xihua University, Chengdu 611930)

Received:2010-02-26 Revised:2010-05-06 Published:2010-06-03
Contact: Hua Chen E-mail:scuhchen@163.com

Abstract

A new diphosphine, 6,6 -dimethoxy-2,2 -bis(di-2-pyridylphosphino)-1,1 -biphenyl (DPP), has been synthesized from commercially available 3-bromoanisole in four steps and fully characterized by ¹H NMR, ³¹P NMR, ¹³C NMR and HRMS techniques. The palladium complex of the new ligand DPP provided excellent yields in Suzuki-Miyaura coupling reaction of aryl bromides with phenyl boronic acid, even in the presence of hindered and functional groups.

Key words: Suzuki-Miyaura cross-coupling, diphosphine, aryl halide, synthesis

Cite this article

PENG Zong-Hai, MA Meng-Lin, FU Hai-Yan, CHEN Hua. Synthesis of a New Biphenyl Diphosphine Ligand and Its Pd-Catalyzed Suzuki-Miyaura Reaction[J]. Chin. J. Org. Chem., 2010, 30(10): 1529-1534.

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新型联苯类双膦配体的合成及钯催化Suzuki-Miyaura反应

Synthesis of a New Biphenyl Diphosphine Ligand and Its Pd-Catalyzed Suzuki-Miyaura Reaction

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