Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (6): 542-545. Previous Articles     Next Articles

手性(Salen)CO催化的末端环氧化合物水解动力学拆对反应在手性药物合成中的应用

沈凯圣;熊飞;胡娟;杨琍苹   

  1. 华东师范大学化学系
  • 发布日期:2003-06-25

Application of Chiral (Salen) Co-Catalyzed Hydrolytic Kinetic Resolution of Racemic Terminal Epoxides to the Syntheses of Chiral Drugs

Shen Kaisheng;Xiong Fei;Hu Juan;Yang Liping   

  1. Department of Chemistry,East China Normal University
  • Published:2003-06-25

The hydrolytic kinetic resolution (HKR) of racemic terminal epoxides catalyzed by chiral (salen)Co could afford optically active terminal epoxides. Chiralβ -amino alcohol and β-alkoxyl alcohol derivatives which are biologically important could be obtained by the ring-opening reactions of chiral terminal epoxides with amines and alkoxy anions. Application of this approach to the syntheses of chiral drugs, T-588 and (R)-albuterol is described.

Key words: COBALT, CATALYST, EPOXIDE, HYDROLYSIS, DYNAMICS, (R)-albuterol

CLC Number: