Synthesis and Antibacterial Activities of Novel Pyrazole Schiff  Bases and Metal Complexes

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (9): 1387-1391. Previous Articles Next Articles

Original Articles

新型吡唑Schiff碱及金属配合物的合成和抑菌活性

程青芳*,a,b 许兴友b,c 王启发a 张莉c
林俏c 张君磊c 杨绪杰b

(a淮海工学院江苏省海洋生物技术重点实验室连云港 222005)
(b南京理工大学材料化学实验室南京 210094)
(c淮海工学院化学工程系连云港 222005)

收稿日期:2008-12-17 修回日期:2009-02-24 发布日期:2009-12-30
通讯作者: 程青芳

Synthesis and Antibacterial Activities of Novel Pyrazole Schiff Bases and Metal Complexes

Cheng, Qingfang ^*,a,b Xu, Xingyou ^b,c Wang, Qifa ^a Zhang, Li ^c
Lin, Qiao ^c Zhang, Junlei ^c Yang, Xujie ^b

(^a Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology, Lianyungang 222005)
(^b Materials Chemistry Laboratory, Nanjing University of Science and Technology, Nanjing 210094)
(^c Department of Chemical Technology, Huaihai Institute of Technology, Lianyungang 222005)

Received:2008-12-17 Revised:2009-02-24 Published:2009-12-30
Contact: Cheng, Qingfang

Abstract

Ten novel pyrazole Schiff bases derived from 3-amino-4-cyanopyrazole and aromatic aldehydes, and four metal complexes of Cu(II), Ni(II), Zn(II), and Co(II) have been synthesized and characterized by elemental analysis, IR, 1H NMR, and X-ray analysis. The antibacterial activities have been screened for these compounds against four bacteria: Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa. The primary biological activity assay showed that all products exhibited medium to high antibacterial activities against Staphylococcus aureus, Escherichia coli and Pseudomonas aerugi-nosa. Cu(II) and Zn(II) complexes had the most intense antibacterial activities against Staphylococcus aureus and Escherichia coli.

Key words: 3-amino-4-cyanopyrazole, metal complex, antibacterial activity, pyrazole Schiff base

Cite this article

Cheng, Qingfang ^*,a,b Xu, Xingyou ^b,c Wang, Qifa ^a Zhang, Li ^c
Lin, Qiao ^c Zhang, Junlei ^c Yang, Xujie ^b
. Synthesis and Antibacterial Activities of Novel Pyrazole Schiff Bases and Metal Complexes[J]. Chin. J. Org. Chem., 2009, 29(9): 1387-1391.

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新型吡唑Schiff碱及金属配合物的合成和抑菌活性

Synthesis and Antibacterial Activities of Novel Pyrazole Schiff Bases and Metal Complexes

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