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Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (12): 1586-1589. Previous Articles     Next Articles

Reports

微波辐射下合成5-(2-甲基/三氟甲基-苯并咪唑-1-亚甲基)-3-(苯基/p-取代苯基)-2H-1',2',4'-三唑[3,4-b]-1

张万权，李燕萍，刘晨江*，王吉德   

  1. (新疆大学化学化工学院 石油天然气精细化工教育部重点实验室 乌鲁木齐 830046)
  • 收稿日期:2007-01-04 修回日期:2007-03-22 发布日期:2007-12-04
  • 通讯作者: 刘晨江

Synthesis of 5-(2-Methyl/trifluoromethyl-benzimidazol-1-ylmethyl)-3-[p-(un)substituted phenyl]-2H-1',2',4'-triazolo[3,4-b]-1

ZHANG Wan-Quan, LI Yan-Ping, LIU Chen-Jiang*, WANG Ji-De   

  1. (Key Laboratory of Oil and Gas Fine Chemicals of Ministry of Education, School of Chemistry and
    Chemical Engineering, Xinjiang University, Urumqi 830046)
  • Received:2007-01-04 Revised:2007-03-22 Published:2007-12-04
  • Contact: LIU Chen-Jiang

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A series of novel 1,2,4-triazolo[3,4-b]-1',3',4'-thiadiazine derivatives 4a～4e and 5a～5e were synthesized by the reaction of 1-amino-2-(2-methyl/trifluoromethyl-benzimidazol-1-ylmethyl)-5-mercapto- 1,3,4-triazole with α-bromoacetophenones 3a～3e under microwave irradiation or heating. After comparison, it was found that the microwave irradiation process had many advantages of shorter time, higher yield and less secondary reaction. The structures of all the new compounds were confirmed by elemental analysis, IR, 1H NMR and MS spectra.

Key words: benzimidazole, 1,2,4-triazolo[3,4-b]-1',3',4'-thiadiazine, synthesis, microwave irradiation