A new group of azidosalicylamides were prepared from nitrosalicylamides by means of reduction, diazotization and azidolation. The nitrosalicylamides with a shorter chain may be reduced by Sn+HCl, whereas the nitrosalicylamides with a longer side chain may be reduced by H~2-Pd/C in good yields. The structrues of the products obtained were characterized by IR, ^1H NMR, Mass spectra and elemental analysis . The new azidosalicylamides synthesized have been used successfully as a new type of molecular probe for mitochondrial respiratory chain enzymes study.

Key words: AMIDES P, MOLECULAR PROBE, STRUCTURE CHARACTERISTICS, DIAZOTIZATION, ENZYME INHIBITOR, OXIDOREDUCTASES, ORGANIC SYNTHESIS, REDUCTION REACTION, AZIDE